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J.Physiol.-Renal Physiol. 2008 May;294(5):F1032-47 (invited review).[6]. Zhang X, Yu S, Galson D, Luo M, Fan J, Zhang J, Guan Y, Xiao G. Activating transcriptionfactor 4 is critical for proliferation and survival in primary bone marrow stromal cells andcalvarial osteoblasts. J Cell Biochem. 2008 Oct 15;105(3):885-95;[7]. Zhou Y, Wu J, Zhang X, Yang G, ChenL, Wei M, Zhang Y, Breyer MD, Guan Y*:Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats. Am.J. Physiol.-Renal Physiol. 2008 Sep;295(3):F662-71.[8]. Zhang H, Li Y, Fan Y, Wu J, Zhao B, Guan Y, Chien S, Wang N. Klotho is a target gene ofPPAR-gamma. Kidney Int. 2008 Sep;74(6):732-9[9]. Wu J, Chen L, Zhang D, Huo M, Pu D and Guan Y*: Peroxisome proliferator-activatedreceptors and renal diseases. Front Biosci. 2009 Jan 1;14:995-1009. (invited review).[10]. Wang J, Bai L, Li J, Sun C, Zhao J, Cui C, Han K, Liu Y, Zhuo X, Wang T, Liu P, Fan F,Guan Y, Ma A. Proteomic analysis of mitochondria reveals a metabolic switch from fattyacid oxidation to glycolysis in the failing heart. Sci China C Life Sci. 2009Nov;52(11):1003-10.[11]. Yang J, Zhang D, Li J, Zhang X, Fan FL and Guan Y*: Role of PPARγ in renoprotection intype 2 diabetes: molecular mechanisms and therapeutic potential. Clinical Science 2009Jan;116(1):17-26.[12]. Xu G, Li Y, An W, Li S, Guan Y, Wang N, Tang C, Wang X, Zhu Y, Li X, MulhollandMW, Zhang W. Gastric mammalian target of rapamycin signaling regulates ghrelinproduction and food intake. Endocrinology. 2009 Aug;150(8):3637-44;[13]. Xie X, Liao H, Dang H, Pang W, Guan Y, Wang X, Shyy JY, Zhu Y, Sladek FM.Down-regulation of hepatic HNF4alpha gene expression during hyperinsulinemia viaSREBPs. Mol Endocrinol. 2009 Apr;23(4):434-43;[14]. Tsai MC, Chen L, Zhou J, Tang Z, Hsu TF, Wang Y, Shih YT, Peng HH, Wang N, Guan Y,Chien S, Chiu JJ. Shear Stress Induces Synthetic-to-Contractile Phenotypic Modulation inSmooth Muscle Cells via Peroxisome Proliferator-Activated Receptor {alpha}/{delta}Activations by Prostacyclin Released by Sheared Endothelial Cells. Circ Res. 2009;105:471-480;[15]. Zhang H, Wang WP, Guo T, Yang JC, Chen P, Ma KT, Guan Y, Zhou CY. TheLIM-Homeodomain Protein ISL1 Activates Insulin Gene Promoter Directly throughSynergy with BETA2. J Mol Biol. 2009; 392(3):566-77;[16]. Cheng H, Fan X, Guan Y, Moeckel GW, Zent R, Harris RC. Distinct roles for basal andinduced COX-2 in podocyte injury. J Am Soc Nephrol. 2009 Sep;20(9):1953-62.[17]. Miao J, Fan Q, Cui Q, Zhang H, Chen L, Wang S, Guan N, Guan Y, Ding J. Newlyidentified cytoskeletal components are associated with dynamic changes of podocyte footprocesses. Nephrol Dial Transplant. 2009; 24(11):3297-3305[18]. Ruan X and Guan Y*: Metabolic syndrome and chronic kidney disease. Journal of Diabetes2009;1:236-245[19]. Chen L, Yang G, Zhang X, Wu J, Gu Q, Wei M, Zhu Y, Wang N, Guan Y*: Induction ofMIF expression by oxidized LDL via activation of NF-κB in vascular smooth muscle cells.Atherosclerosis 2009 Dec;207(2):428-33;[20]. Wang Q, Zhang Y, Lu M, Guan Y, Zhu Y, Wang Y. Renal over expression of solubleepoxide hydrolase in rat with hypertension induced by high-salt]. Beijing Da Xue Xue Bao.- 4 -