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About authorsthe toxicokinetics of two fungicides widely used in agriculture, and for whichtoxicological data were very limited in humans. As postdoctoral researcher, sheis currently carrying out toxicokinetics studies on dermal route using an in vitrosystem. The studied compounds are mainly pesticides and biocides. She is a SOTmember and participates in an expert group on pesticide exposure.Michele Bouchard is an associate professor in the Department of Environmentaland Occupational Health of the University of Montreal. She is head of the Chair inToxicological Risk Assessment and Management of the University and head of theBiomarker Unit of the Xenobiotics and Nanoparticles plateform funded by CanadaFoundation for Innovation. Her researches aim at better assessing toxicologicalhealth risks in humans associated with environmental and occupational exposures tochemical compounds through the use of biomonitoring and toxicokinetic modeling.Studied contaminants include natural pyrethrins, pyrethroids, phthalimides,organophosphorus insecticides, carbamates, polychlorinated biphenyls, polycyclicaromatic hydrocarbons, formaldehyde, selenium, mercury, arsenic, acrylamide andnanoparticles of titanium dioxide.Mathieu Valcke has a Bachelor’s degree in biochemistry and a Ph.D. in toxicologyand risk assessment from the University of Montreal. He cumulates more than 10years of experience in the field of public health, more specifically on topics relatedto the health risk assessment of environmental contaminants in soils, food andwater. He also realized studies on the exposure and health risk related to the useof pesticides. He currently holds a position as the Chief scientific advisor of theToxicological risk assessment Group at the National Institute of Public Health ofthe Province of Quebec, Canada, and has a clinical adjunct professor affiliation atthe Department of Environmental and Occupational Health of the University ofMontreal.Roberto Heredia Ortiz is a research assistant in the Department of Environmentaland Occupational Health of the University of Montreal. He worked on thedevelopment of models to reconstruct exposure to phthalimide fungicides frombiomarker data, predict main exposure routes in workers and propose biologicalreference values. He is currently doing his Ph.D. in the Department on thecomparison of toxicokinetic models and physiologically-based toxicokinetic modelsto describe the kinetics of benzo(a)pyrene biormarker, 3-hydroxybenzo(a)pyrene.Influence of Organochlorine Pesticides on GH-IGF System, p.143-p.153Luis D. Boada, Luis A. Henríquez-Hernández, Manuel Zumbado, Maira Almeida-González, Pilar F. Valerón, Octavio P. LuzardoAbout authors:The authors belong to the Research Group in Environment and Health, Universityof Las Palmas de Gran Canaria (Spain). This is an interdisciplinary group composedAcademyPublish.org - The Impact of Pesticides10
About authorsof medical researchers, veterinarians, biologists and pharmacists with extensiveexperience in studies involving monitoring of persistent organic pollutants (POPs)in human populations, and the toxic effects induced by environmental persistentorganic pollutants, among them organochlorine pesticides, on human beings.Contacts:Luis D. Boada PhD, MD; Research Group in Environment and Health; ToxicologyUnit. Dept. of Clinical Sciences. University of Las Palmas de Gran Canaria(Spain) and Instituto Canario de Investigación del Cáncer (ICIC). E-mail address:ldominguez@dcc.ulpgc.es. Phone: 34928453472.Luis A. Henríquez-Hernández, PhD, VD; Research Group in Environment andHealth; Toxicology Unit. Dept. of Clinical Sciences. University of Las Palmas deGran Canaria (Spain) and Instituto Canario de Investigación del Cáncer (ICIC). ).E-mail address: lhenriquez@dcc.ulpgc.es. Ph: 34928451461.Manuel Zumbado, Research Group in Environment and Health; ToxicologyUnit. Dept. of Clinical Sciences. University of Las Palmas de Gran Canaria (Spain)and Instituto Canario de Investigación del Cáncer (ICIC). ). E-mail address:mzumbado@dcc.ulpgc.es. Ph: 34928453472.Maira Almeida-González, PhD, VD; Research Group in Environment and Health;Toxicology Unit. Dept. of Clinical Sciences. University of Las Palmas de GranCanaria (Spain) and Instituto Canario de Investigación del Cáncer (ICIC). ). E-mailaddress: malmeida@dcc.ulpgc.es. Ph: 34928451461.Pilar F. Valerón, PhD, BD; Research Group in Environment and Health;Toxicology Unit. Dept. of Clinical Sciences. University of Las Palmas de GranCanaria (Spain) and Instituto Canario de Investigación del Cáncer (ICIC). ). E-mailaddress: jfernandez@dbbf.ulpgc.es. Ph: 34928451421.Octavio P. Luzardo, PhD, VD; Research Group in Environment and Health;Toxicology Unit. Dept. of Clinical Sciences. University of Las Palmas de GranCanaria (Spain) and Instituto Canario de Investigación del Cáncer (ICIC). ). E-mailaddress: operez@dcc.ulpgc.es. Ph: 34928451424.AcademyPublish.org - The Impact of Pesticides11
Page 1 and 2: The Impactof PesticidesEdited by:Pr
Page 3 and 4: Other access free resources from Ac
Page 5 and 6: The Impact of PesticidesPrepared an
Page 7 and 8: Table of Contentsp.203-p.224 Behavi
Page 9: About authorspublished by Elsevier.
Page 13: About authorsdifferent spatial scal
Page 16 and 17: About authorsEducation:Bachelor’s
Page 18 and 19: About authorsSensors - A Nanotechno
Page 20 and 21: Section 1HUMAN EXPOSURE TO PESTICID
Page 22 and 23: ecently explored on preliminary stu
Page 24: individuals within 1 day (Jokanovic
Page 27 and 28: occupational environmental health r
Page 30 and 31: must be considered, since effective
Page 34 and 35: Jensen BH, Petersen A, and Christen
Page 36 and 37: Ragas AMJ, and Huijbregts MAJ (1998
Page 38 and 39: Weichenthal S, Moase C, and Chan P
Page 40 and 41: human poisoning, general acute symp
Page 42 and 43: Management of the cholinergic syndr
Page 44 and 45: 1982; Lotti, 1992; Jokanović et al
Page 46 and 47: exposed populations, revealed high
Page 48 and 49: DiazepamBenzodiazepines are CNS dep
Page 50 and 51: Among the many classes of oximes in
Page 52 and 53: inhibited by dichlorvos (a dimethox
Page 54 and 55: Dawson, 1995). It appears that the
Page 56 and 57: Eddleston M, Eyer P, Worek F, Moham
Page 58 and 59: Jokanović M, Kosanović M (2010b).
Page 60 and 61:
Ray DE (1998). Chronic effects of l
Page 62 and 63:
Worek F, Eyer P, Kiderlen D, Thierm
Page 64 and 65:
developing countries is due to suic
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count and morphology, as well as se
Page 68 and 69:
PON1 modulation of genetic damageFe
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elationship between OP exposure and
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Blatter-Garin MC, James RW, Dussoix
Page 74 and 75:
Hung RJ, Hall J, Brennan P, Boffett
Page 76 and 77:
Rojas-García AE., Solís-Heredia M
Page 78 and 79:
Occupational Exposure to Pesticides
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considered as conditions typical of
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observed adverse health outcome. Su
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within cells can oxidize biomolecul
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of the study. A face-to-face questi
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PesticidesFungicideInsecticide-Nema
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Table 4. Mixtures of pesticides use
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In pesticide applicators, Table 7 s
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DISCUSSIONThe agricultural workers
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changes in the antioxidant enzyme C
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Bajpayee, M.; Pandey, A. K.; Parmar
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Environmental health criteria 155.
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Palus, J.; Rydzynski, K.; Dziubalto
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Singh, N.P.; McCoy, M.T.; Tice, R.R
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INTRODUCTIONPopulations may be occu
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exposure scenarios on the basis of
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not present adverse health effects
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greenhouse workers exposed to malat
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Paraoxon is then either metabolized
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cyclohexene-1,2-dicarboximide, CAS
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metabolite of phthalates, such that
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scenarios were simulated, assuming
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Table 2. Biological reference value
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References N a urinarybiomarkeStudi
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Figure 2. Representation of a BRV d
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Figure 4. Conceptual representation
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Figure 6 Conceptual representation
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REFERENCESACGIH, 2011. Documentatio
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Bradway, D.E., Shafik, T.M., 1977.
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EPA, 1999b. Registration Eligibilit
Page 138 and 139:
Hines, C.J., Deddens, J.A., Jaycox,
Page 140 and 141:
McCollister, S.B., Kociba, R.J., Hu
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Verberk, M.M., Brouwer, D.H., Brouw
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important IGFBP for binding IGF-1 i
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secretion of IGF-1 (Tannheimer et a
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FIGURESFig. 1. An “hormetic” ef
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Landi F, Capoluongo E, Russo A, Ond
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Smith WJ, Underwood LE, Clemmons DR
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Section 2PESTICIDES IN THEENVIRONME
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vicinity of subsoil waters and ther
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Hieracium pilosella, southernwood -
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formed clusters (Figure 3). Ultrast
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Fig. 5. Fragment of hepatocyte of t
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Szarek, J, Skibniewska, K, Wojtacka
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negative effects (ZALUCKI et al., 2
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Figure 2. Appropriated sampling pro
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Figure 4. Illustration of the conse
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(HAILE et al., 1998). Earlier resul
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Table 1. Distribution of the applic
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Means followed by the same letter i
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(involving pests and natural enemie
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efore the pest emergence and their
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Table 3 (continuation)…AcademyPub
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Table 5. Effect of different fungic
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Table 6. Magament used including do
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adopted by Brazilian soybean grower
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Pickle, C.S.; Caviness, C.E. Yield
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This chapter reports on Dutch surfa
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several different occasions at any
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The greatest number of pesticides a
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Accumulated ExceedanceIt is useful
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For the years 2003-2009 the calcula
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Bonzini S, Verro R, Otto S, Lazzaro
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atios of the pesticide amounts in t
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Table 1. (Cont.) Runoff ratios of p
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mefenacet and simetrin were observe
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Table 2. (Cont.)Pesticide concentra
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Table 2. (Cont.)Pesticide concentra
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Fig. 3. Typical weekly variation of
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(BAM) in water (Pukkila et al. 2009
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Table 5. Concentrations of pesticid
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Table 6. Maximum concentrations of
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Iwafune, T, Inao, K, Horio, T, Iwas
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Suzuki, M, Takemine, S, Yoshida, M,
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factor, etc. Levels of pesticides i
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factor of 10 above ambient sea wate
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weight sample. Minimum were shown f
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Figure 3. DDTs in mussel samples fo
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Figure 5. HCB in mussel samples for
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Figure 8. Methoxychlor in mussel sa
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ACKNOWLEDGEMENTAuthors thank UNEP/M
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Pesticide Risk Index of Del Azul Wa
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on that presented in Swanson et al.
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eference value for that substance.
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predict the aquatic toxicity of a s
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Calculation Model of Aggravating Fa
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To estimate the values of Human Hea
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water in comparison with the durati
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Cypermethrin (95 th percentile (P 9
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Table 8 shows the results of the De
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are many ranking systems of dangero
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REFERENCESAres J. (2004). “Estima
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Mackay D. and Paterson S. (1991).
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Long-term Monitoring of Pesticides
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Sampling sites of the survey in 200
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than those in Lake Biwa and Seta Ri
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Fig. 7 Detection of fungicides in R
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Fig. 11 Detection of herbicides in
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Monitoring of pesticides in Yanamun
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A measured volume (1000 mL) of the
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SimetrynePretilachlorConcentration
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Fig. 18 Maximum concentrations of t
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Ecological risk assessmentFig. 20 Y
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REFERENCESAgradi E, Baga R, Cillo F
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Time Trend Variation of Selected Pe
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Table 1. Physical and chemical prop
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marketed under variety of trade nam
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Figure 3. Long-term trends of globa
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laboratory animals fed or injected
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fed for a lifespan at 5-1,600 mg/kg
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Soil samplingSoil sampling was foll
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Figure 5. Map showing sampling area
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concentration (MAC) in surface soil
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Table 7. Concentrations of HCH isom
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Shanghai and Guanting Reservoir (Ch
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Contrary to the results of ΣDDT, t
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DDT metabolites, the ratio of (p,p
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2001). Therefore, the predominance
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Mean concentration (ng g -1 dw)3002
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CONCLUSIONSAn evaluation of selecte
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Hung, D.Q., Thiemann, W., (2002),
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Viet, P.H., Hoai, P.M., Minh, N.H.,
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found in tissues or fluids samples
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Study area and SamplingThis study w
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the liver, mainly to p,p'-DDE and p
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33,370 ha, whilst that of woody cro
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Increase in crops area (x1000)Ha)25
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Table 1. Blood concentrations of or
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Council Directive 90/533/EEC of 15
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Konstantinou, IK, Goutner, V, Alban
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Smith, AG (2004). “Toxicology of
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Pesticides are used in order to pro
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EXPERIMENTALMaterialsIsoproturon wa
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RESULTS AND DISCUSIONEquilibrium is
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As seen in Table 4, as the concentr
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Fig.4. Breakthrough curves of isopr
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Fig.6. Breakthrough curves of isopr
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Fig.8. Experimental and theoretical
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Section 3PESTICIDE ANALYSISAcademyP
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scandal’ are familiar to the gene
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ecoveries (>70%) for certain pH-dep
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Due the versatility of the QuEChERS
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of application, with some still sca
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The main supercritical solvent used
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extracting the pesticides from the
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would be appropriate for the routin
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chromatography with negative-ion el
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GPC was applied as a nondestructive
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Charlton A.J.A., Stuckey, V. (2009)
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Lehotay, S.J., Mastvoska, K. & Yun,
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Rodrigues, F. M., Mesquita, P. R. R
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Analytical methods to assess the im
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acetylcholine, a neurotransmitter t
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1.3 to 22.3% for all pesticides. Li
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Malathion, parathion, fenitrothion,
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Fuller, BH and Berger, GMB (1990).
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Table 1. Largest exporters of coffe
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Fig. 1: Structures of (a) Phosphate
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ELECTROCHEMICAL BIOSENSORBiosensors
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inorganic and organic species a lar
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surface area and be easily modified
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Acetylcholine + H 2 O AChE Choline
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Wang, 2010) and tetracyanoquinodime
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PDDA/AChE/PDDA/CNT/GCAChE-Au-PPy/GC
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ng/mL and good precision (RSD ) 5.3
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FUTURE PERSPECTIVESThe detection of
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Du, D; Wang, M; Cai, J; Qin, Y; Zha
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Martorell, D; Cespedes, F; Fabreaga
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The Pesticide Action Network (PAN).
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About EditorMilan JokanovićProfess
Page 418:
THE IMPACT OF PESTICIDESPesticides
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