The Impact of Pesticides - Academy Publish

examples highlight the importance of knowledge on urine collections (i.e. spotsamples or timed-collections), sampling strategies, metabolism, relative proportion ofdifferent metabolites in the sampled matrix, route of exposure and backgroundcontribution of prior exposures. It also shows that focusing the approach on specificurinary biomarkers appears more accurate in the case of occupational exposure.Conversely, applying the approach to non-specific metabolites, but common to acategory of pesticides, appears more accurate for environmental risk assessment wherethe pesticides to which subjects are exposed are unknown. The BRVs derived with themodeling approach may be readily used to provide a health-based interpretation ofexposure in workers and the general population as well as facilitate health riskmanagement of pesticides by public health authorities.Table 1. First-order linear differential equations describing the kinetics of a genericmodel.CompartmentGastrointestinaltractDifferential equationsSkinPesticide inblood and tissuesin equilibriumwith bloodMetabolite inblood and tissuesin equilibriumwith bloodPesticide in urineMetabolite inurineAcademyPublish.org - The Impact of Pesticides121