The Impact of Pesticides - Academy Publish

FIGURESFig. 1. An “hormetic” effect( “U” shaped dose-response curve)was observed betweenTotal cyclodienes Body Burden (sum of serum levels of aldrin, dieldrin and endrin)and IGF-1 in men.200IGF-I serum levels (ng/ml)190180170P = 0.024T1T3T2160Cyclodienes(Aldrin + Dieldrin + Endrin)DDTs(DDT + DDE + DDD)Male AdultsubjectsREFERENCESBach LA, Headey SJ, Norton RS (2005). “IGF-binding proteins- the pieces are fallinginto place”. Trends in Endocrinol Metabolism, Vol 16, pp 228-234.Baibas N, Bamia C, Vassilopoulou E, Sdrolias J, Trichopoulou AA, Trichopoulos D.(2003). “Dietary and lifestyle factors in relation to plasma insulin-like growth factor Iin a general population sample”. Eur J Cancer Prev, Vol 12, pp 229-234.Boada LD, Lara PC, Álvarez-León EE, Losada A, Zumbado M, Limiñana-Cañal JM,Apolinario R, Serra-Majem L, Luzardo OP. (2007). “Serum levels of insulin-likegrowth factor-I in relation to organochlorine pesticides exposure”. Growth Horm IGFRes, Vol 17, pp 506-511.Ceccatelli R, Faas O, Schlumpf M, Lichtensteiger W( 2006). “Gene expression andestrogen sensitivity in rat uterus after developmental exposure to the polybrominateddiphenylether PBDE 99 and PCB”. Toxicology, Vol 220, pp 104-116.Cheema U, Brown R, Mudera V, Yang SY, McGrouther, Goldspink G (2005).“Mechanical signals and IGF-1 gene splicing in vitro in relation to development ofskeletal muscle”. J Cell Physiol, Vol 202, pp 67-75.Chellakooty M, Juul A, Boisen KA, Damgaard IN, Kai CM, Schmidt IM, Petersen JH,Skakkebaek NE, Main KM (2006). “A prospective study of serum insulin-like growthfactor I (IGF-I) and IGF-binding protein-3 in 942 healthy infants: associations withbirth weight, gender, growth velocity, and breastfeeding”. J Clin Endocrinol Metab,Vol 91, pp 820-826.AcademyPublish.org - The Impact of Pesticides148