Proceedings Volume 2010 (format .pdf) - SimpBTH

TNF-α (pg/ml)10009008007006005004003002001000PHA+LPS 0.001 0.01 0.1 1 10 100RZ µg/mlFig.3. The effect of RZ on modulating TNF-α production after PHA+LPS stimulationTwenty-four hour exposure at different concentrations of RZ increasedsignificantly (p < 0.001) the production of IL-10, from PHA+LPS-stimulatedwhole blood (fig.4). No significant changes in the production of IL-2, IL-4 and IL-8 were seen.These results indicate that RZ inhibits proinflammatory cytokines productionand increase IL-10 level in a concentration dependent manner.The differential effect of RZ on cytokines opens several ideas for applications.Those effects should be studied further in animal models to check the efficacy ofsuch cytokine inhibition and/or induction.12001000IL-10 (pg/ml)8006004002000PHA+LPS 0.001 0.01 0.1 1 10 100RZ µg/mlFig. 4. The effect of RZ on modulating IL-10 production after PHA+LPS stimulation243