Proceedings Volume 2010 (format .pdf) - SimpBTH

Based on all the above observations, we suggest a possibleimmunomodulatory role for Rosmarinus officinalis as it relates to inflammation.CONCLUSIONSThe selective extract obtained from Rosmarinus officinalis L.(RZ) modulatescytokines production by PHA+LPS stimulated whole blood.The results showed increased expression IL-10 (anti-inflammatoryinterleukin) and inhibition of proinflammatory interleukins (IL-1β, TNF-α, and IL-6) production after treatment with the selective extract, in a concentrationdependent manner.This findings suggest that Rosmarinus officinalis and its compounds could beused to reduce inflammatory reactions in certain inflammatory diseases.REFERENCES1. Dinarello C.A., (2010) IL-1: discoveries, controversies and future directions. Eur. J. Immunol.,Vol.40(3):599-6062. Nishimoto N., (2010) Interleukin-6 as a therapeutic target in candidate inflammatory diseases. Clin.Pharmacol. Ther., Vol. 87(4):483-7.3. Elenkov IJ, Chrousos GP., (1999) Stress hormones, Th1/Th2 patterns, pro/anti-inflammatorycytokines and susceptibility to disease. Trends Endocrinol Metab, Vol.10:359–68.4. Mu HH, Sawitzke AD, Cole BC., (2010) Modulation of cytokine profiles by the Mycoplasmasuperantigen Mycoplasma arthritis mitogen parallels susceptibility to arthritis induced by M.arthritidis. Infect Immun, Vol.68:1142–9.5. Yu J, Ren X, Cao S, Zhang W, Hao X.(2006) Th1 polarization and apoptosis-inducing activity ofCD4+ T-cells in cytokine-induced killers might favor the antitumor cytotoxicity of cytokineinducedkillers in vivo. Cancer iother Radiopharm, Vol.21:276–84.6. Matalka KZ., (2003), Prolactin enhances the production of interferon-c, interleukin-12, interleukin-10, but not of tumor necrosis factor-a, in a stimulus specific manner. Cytokine Vol.21:187–94.7. Mahmoud A.A., Al-Shihry S.S., Son B.W., (2005), Diterpenoid quinones from rosemary(Rosmarinus officinalis L.). Phytochemistry, Vol. 66(14):1685-908. Yesil-Celiktas O., Sevimli C., Bedir E., Vardar-Sukan F., (2010), Inhibitory effects of rosemaryextracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines. PlantFoods Hum Nutr., Vol. 65(2):158-639. Farmacopeea romana, ed.a X-a, Bucuresti, Ed. Medicală, 1993, p 335.10.***European Pharmacopeea, ed.6.0, Monographia Rosemary leaf, p. 2840;11. Balaban, A.T., Banciu, M., Pogany, I.: Applications of physical methods in organic chemistry,Bucuresti. Ed. Stiinţifică- Enciclopedică, 1983, p23.AcknowledgmentThis paper was supported by the Romanian National Authority for Scientific Research,Project No 61014/14.09.07. Authors gratefully aknowledge its financial support.244