Rezümékötet 2008. - vmtdk

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É L Õ T E R M É S Z E T T U D O M Á N Y O K
called familial tumors. The familial tumor syndrome is wellknown in colorectal, breast and multiple endocrine neoplasia.
These tumors follow Mendel’s inheritance pattern, and most frequently their inheritance is autosomal dominant.
Most of the patients are young and have multiplex tumors. According to our present knowledge, the cell cycle
and the tumorigenesis are regulated by three gene families. These are the oncogenes, the suppressor genes and the
DNS mismatch repair genes. These latter ones play a role in the development of the hereditary nonpolyposis colon
carcinoma.
Methods: We examined the development, especially the triggering factors and the gene mutations, of colorectal
carcinomas that show familial occurrence. As our own case, we present a patient of the Department of Medical Genetics
of our university, and his family where colon carcinoma is inherited.
Conclusion: According to data from literature and our own examinations, we think the examination of familial
tumors is extremly important, because it helps to get to know better the certain parts of carcinogenesis. As the result
of the examinations, an opportunity for screening, prevention and early diagnosis arises. Thus, the patient’s life, and
its quality would imporve considerably.
Keywords: familial tumor, oncogens, tumor suppressor genes, colorectal cancers
V I I . V A J D A S Á G I M A G Y A R T U D O M Á