4.3.1 Sintesi e raccomandazioni - Biblioteca Medica
4.3.1 Sintesi e raccomandazioni - Biblioteca Medica
4.3.1 Sintesi e raccomandazioni - Biblioteca Medica
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
In conclusione i risultati di questa valutazione mostrano come il rapporto costo efficacia<br />
della combinazione sia comunque decisamente elevato se confrontato con i valori di accettabilità<br />
definiti a livello internazionale (p. es. un costo di $30.000 per anno di vita salvato [15]).<br />
Quindi, tenendo conto dell’attuale prezzo dei farmaci, la terapia combinata pare non avere<br />
una compatibilità economica accettabile per il nostro SSN, se non per specifici pazienti<br />
selezionati, cioè quelli ad alto rischio di progressione. Qualora in futuro si rendessero disponibili<br />
i dati dell’impatto della combinazione 5ARI e α 1<br />
-litici sulla qualità di vita dei pazienti,<br />
l’analisi dovrebbe essere rivista tenendo conto di questi risultati.<br />
6.2.5.2. Bibliografia<br />
1. Johnson NJ, Kirby RS. Treatments for benign prostatic hyperplasia: An analysis of their<br />
clinical and economic impact in the United Kingdom and Italy. J Outcomes Res, 1999:<br />
3, 11-26.<br />
2. Lowe FC, McDaniel RL, Chmiel JJ, Hillman AL. Economic modeling to assess the costs of<br />
treatment with finasteride, terazosin, and transurethral resection of the prostate for men<br />
with moderate to severe symptoms of benign prostatic hyperplasia. Urology, 1995: 46,<br />
477-483.<br />
3. Cockrum PC, Finder SF, Ries AJ, Potyk RP. A pharmacoeconomic analysis of patients with<br />
symptoms of benign prostatic hyperplasia. Pharmacoeconomics, 1997: 11, 550-565.<br />
4. McConnell JD, Barry MJ, Bruskewitz RC et al Benign prostatic hyperplasia: diagnosis and<br />
treatment. Agency for Health Care Policy and Research. Clin Pract Guide/Quick Ref<br />
Guide Clin 1994 AHCPR Publication N 94-0582<br />
5. Albertsen PC, Pellissier JM, Lowe FC, Girman CJ, Roehrborn CG. Economic analysis of<br />
finasteride: A model-based approach using data from the Proscar long-term efficacy<br />
and safety study. Clin Ther, 1999: 21, 1006-1024<br />
6. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting<br />
enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and<br />
Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA, 2002:<br />
288, 2981-97<br />
7. Hillman AL, Schwartz JS, Willian MK, Peskin E, Roehrborn CG, Oesterling JE, Mason<br />
MF, Maurath CJ, Deverka PA, Padley RJ. The cost-effectiveness of terazosin and placebo<br />
in the treatment of moderate to severe benign prostatic hyperplasia. Urology, 1996:<br />
47, 169-178<br />
8. Lanes SF, Sulsky S, Walker AM et al A cost density analysis of benign prostatic hyperplasia<br />
Clin Ther, 1996: 18, 993-1004<br />
9. Oster G, Edelsberg J, Pozniak A, Thompson D. Resource utilisation and costs of treatment<br />
with doxazosin versus tamsulosin in men with benign prostatic hyperplasia. J Outcomes<br />
Res, 2000: 4, 31-40.<br />
10. Baladi JF, Menon D, Otten N. An economic evaluation of finasteride for treatment of<br />
benign prostatic hyperplasia. Pharmacoeconomics, 1996: 9, 443-454<br />
179