Industrial Biotransformations

Alcohol dehydrogenase
Lactobacillus brevis
3) Flow scheme
Fig. 1.1.1.1 – 2
4) Process parameters
yield: 96 %
ee: 99.8 %
reactor type: stirred batch reactor
capacity: 35 t · a –1
space-time-yield: 92 g · L –1 ·d –1
down stream processing: extraction, distillation
enzyme consumption: 80 kU · kg –1
enzyme supplier: Jülich Chiral Solutions, Germany
company: Wacker Chemie, Germany
5) Product application
● Chiral ß-hydroxyesters are important chiral intermediates for organic synthesis.
● They are widely applied as building block for pharmaceuticals, agrochemicals and fragrances.
6) Literature
● Hummel, W. (1997) Biochem. Eng. 58, 145–184
● Hummel, W., Riebel, B. (1999) US 6,225,099 and EP 0796914A2
● Rosen, T.C., Daußmann, T., Stohrer, J. (2004) Speciality Chemicals Magazine, 39–40
EC 1.1.1.1
171