Industrial Biotransformations

Aminoacylase
Aspergillus niger
3) Flow scheme
Not published.
4) Process parameters
ee: >99 %
reactor type: plug-flow reactor
capacity: several kg
down stream processing: solvent extraction
company: Celltech Group plc, U.K.
5) Product application
● The product is used as a component of antihypertensive inhibitors of the enzyme renin, where
it acts as a mimic of histidine.
● Two examples of l-thiazolylalanine-containing inhibitors are:
Fig. 3.5.1.14 – 5
O
1 = thiazolalanine containing inhibitor (Sankyo)
2 = thiazolalanine containing inhibitor (Abbott)
N
O
O
N
O
O
H
N
N
H
N OH O
S
L-1
L-2
H
N
O
OH
H
N
N
H
O N OH
S
N
O
EC 3.5.1.14
405