Industrial Biotransformations

64
3 Retrosynthetic Biocatalysis
3.2
Alkenes
R'
R R'''
R''
X = OH, NH2, SH, halides
lyase
R X
R'''
R' R''
Alkenes can be formed by enzymatic dehydration or elimination of water or alcohols,
amines, thiols or HX using C–X lyases [3].
3.3
Amines
R NH 2
R''
R NH 2
R' R''
R NH2
protease
amidase
oxygenase for
dealkylation
reductase
protease
amidase
transaminase
reductase
reductase
protease
amidase
R N H
R N H
R NO2
R''
R N H
R''
R O
R''
R''
R NH
O
R'
O
R NO 2
R' R''
R N H
O
R'
R'
R'''