Industrial Biotransformations

Lipase
Candida cylindracea
6) Literature
● Adams, S.S., Bresloff, P., Mason, C.G. (1976) Pharmacological differences between the optical
isomers of ibuprofen: evidence for metabolic inversion of the (–)-isomer, J. Pharm. Pharmacol.
28, 256–257.
● Cesti, P., Piccardi, P. (1986) Process for the biotechnological preparation of optically active αarylalkanoic
acids, Montedison S.p.A., Italy, EP 195717 A2
● Lopez, J.L., Wald, S.A., Matson, S.L., Quinn, J.A. (1990) Multiphase membrane reactors for
separating stereoisomers, Ann. N. Y. Acad. Sci., 613, 155–166
● McConville, F.X., Lopez, J.L., Wald, S.A. (1990) Enzymatic resolution of ibuprofen in a multiphase
membrane reactor, in: Biocatalysis (Abramowicz, D.A., ed.) pp.167–177, van Nostrand
Reinhold, New York
● Sheldon, R.A. (1993) Chirotechnology, Marcel Dekker Inc., New York
EC 3.1.1.3
● Sih, C. J. (1987) Process for preparing (S)-α-methylarylacetic acids, Wisconsin Alumni
Research Foundation, USA, EP 227078 A1
● Yamamoto, K., Ueno, Y., Otsubo, K., Kawakami, K., Komatsu, K.I. (1990) Production of (S)-(+)ibuprofen
from a nitrile compound by Acinetobacter sp. Strain AK226, Appl. Environ. Microbiol.
56, 3125–3129
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