Industrial Biotransformations

d-Amino acid transaminase
Bacillus sp.
● Possible products using this synthetic route are:
Fig. 2.6.1.21 – 3
3) Flow scheme
Not published.
4) Process parameters
ee: 100 %
reactor type: batch
capacity: multi t · a –1
down stream processing: crystallization
start-up date: May 1998
production site: NSC Technologies, USA
company: NSC Technologies, Monsanto, USA
5) Product application
● Amino acids are used as food additives and in medicine in infusion solutions.
6) Literature
H 2N COOH
D-alanine
COOH
H 2N COOH
D-glutamic acid
H 2N COOH
H 2N COOH
D-phenylalanine D-leucine
H 2N COOH
D-tyrosine
EC 2.6.1.21
● Ager, D.J., Fotheringham, I.G., Laneman, S.A., Pentaleone D.P., Taylor, P.P. (1997) The largescale
synthesis of unnatural acids, Chim. Oggi, 15 (3/4), 11–14
● Fotheringham, I.G., Pentaleone, D.P., Taylor, P.P. (1997) Biocatalytic production of unnatural
amino acids, mono esters, and N-protected derivatives, Chim. Oggi 15 (9/10), 33–37
● Fotheringham, I.G., Taylor, P.P., Ton, J.L. (1998) Preparation of enantiomerically pure d-amino
acid by direct fermentative means, Monsanto, US 5728555
OH
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