Industrial Biotransformations

d-Lactate dehydrogenase
Leuconostoc mesenteroides
R
Fig. 1.1.1.28 – 2
● In a subsequent step the chiral hydroxy acid is esterified for integration into the chemical synthesis
route of the protease inhibitor.
Fig. 1.1.1.28 – 3
3) Flow scheme
Fig. 1.1.1.28 – 4
180
n
R
O
OAc
n=1
OR'
R
O
n
O
n=0
R
H + "CN - "
n=0
n
M
+
O
n
OH
OH
4M HCl
OH
MeOH
F F
O
O
OH
OR'
2 3
R
R
OH
n
O
n=2
n
O
NH2 n=0-2
O
OMe
O
OH
OR'
EC 1.1.1.28