Industrial Biotransformations

Lipase
Burkholderia plantarii
● The (R)-phenylethylmethoxy amide can be easily hydrolyzed to get the (R)-phenylethylamine:
● The (S)-enantiomer can be racemized using a palladium catalyst.
Fig. 3.1.1.3 – 2
● The following amines can also be used in this process:
Fig. 3.1.1.3 – 3
274
1 = phenylethylmethoxyamide
2 = 1-phenylethylamine
NH2
1-p-tolyl-ethylamine
NH 2
3,3-dimethyl-butyl-2-amine
NH2
1-phenyl-propylamine
NH
O
O
-
O
+ H 2O
(R)-1 (R)-2
O
NH 2
1-(3-methoxy-phenyl)-ethylamine
NH 2
1-naphthyl-ethylamine
NH2
1-ethyl-2-methyl-propylamine
O
OH
Cl
O
NH2
NH2
NH 2
OH
NH2
1-(4-chloro-phenyl)-ethylamine
2-benzyloxy-1-methyl-ethylamine
1-amino-indan-2-ol
EC 3.1.1.3