Industrial Biotransformations

Leucine dehydrogenase
Bacillus sphaericus
6) Literature
EC 1.4.1.9
● Bommarius, A.S., Drauz, K., Hummel, W., Kula, M.-R., Wandrey, C. (1994) Some new developments
in reductive amination with cofactor regeneration, Biocatalysis, 10, 37–47
● Bommarius, A.S., Estler, M., Drauz, K. (1998) Reaction engineering of large-scale reductive
amination processes; Inbio 98 Conference, Amsterdam/NL
● Bommarius, A.S., Schwarm, M., Drauz, K. (1998) Biocatalysis to amino acid-based chiral pharmaceuticals
– examples and perspectives, J. Mol. Cat. B: Enzymatic 5, 1–11
● Bradshaw, C.W., Wong, C.-H., Hummel, W., Kula, M.-R. (1991) Enzyme-catalyzed asymmetric
synthesis of (S)-2-amino-4-phenylbutanoic acid and (R)-2-hydroxy-4-phenylbutanoic acid,
Bioorg. Chem. 19, 29–39
● Kragl, U., Vasic-Racki, D., Wandrey, C. (1996) Continuous production of l-tert-leucine in series
of two enzyme membrane reactors, Bioprocess Engineering 14, 291–297
● Krix, G., Bommarius, A.S., Drauz, K., Kottenhahn, M., Schwarm, M., Kula, M.-R. (1997) Enzymatic
reduction of α-keto acids leading to l-amino acids, d- orl-hydroxy acids, J. Biotechnol.
53, 29–39
● Wichmann, R., Wandrey, C., Bückmann, A.F., Kula, M.-R., (1981) Continuous enzymatic
transformation in an enzyme membrane reactor with simultaneous NAD(H) regeneration,
Biotechnol. Bioeng. 23, 2789–2796
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