Industrial Biotransformations

-Lactamase
Aureobacterium sp.
3) Flow scheme
O
Fig. 3.5.2.6 – 2
4) Process parameters
reactor type: plug-flow reactor with circulation (batch)
down stream processing: extraction, filtration
company: Celltech Group plc, U.K.
5) Product application
● 4-Amino-cyclopent-2-enecarboxylic acid is used as a building block in the synthesis of carbocyclic
nucleosides with the natural configuration.
6) Literature
NH
E
acetone
crystallization
EC 3.5.2.6
● McCague, R., Taylor, S.J.C. (1997) Development of an immobilised lactamase resolution process
for the (+)-γ-lactam and the ring-opened (–)-amino acid, in: Chirality In Industry II (Collins,
A.N., Sheldrake, G.N., Crosby, J., eds.), pp. 187–188, John Wiley & Sons, New York
- OOC
NH 3 +
N
O
421