Industrial Biotransformations

Aminopeptidase
Pseudomonas putida
3) Flow scheme
Fig. 3.4.11.1 – 6
4) Process parameters
ee: > 99 %
reactor type: batch
capacity: ton scale
enzyme activity:
enzyme supplier:
338,000 U · g –1
protein
Novo Nordisk, Denmark
start-up date: 1988
company: DSM, The Netherlands
5) Product application
EC 3.4.11.1
● The α-H-amino acids are intermediates in the synthesis of antibiotics, injectables, food and
feed additives.
● Examples are the antibiotics ampicillin, amoxicillin (see page 290), the sweetener aspartame
(see page 373), several ACE-inhibitors and the pyrethroid insecticide fluvalinate (Fig. 3.4.11.1 – 7).
341