Industrial Biotransformations

Subtilisin
Bacillus licheniformis
5) Product application
● (S)-1 was prepared as an intermediate for the renin inhibitor remikiren:
6) Literature
O O
S
(S)-1
COOH
1 = 2-benzyl-3-(tert-butylsulfonyl)propionic acid
2 = remikiren
Fig. 3.4.21.62 – 2
O O H
S
N
EC 3.4.21.62
● Doswald, S., Estermann, H., Kupfer, E., Stadler, H., Walther, W., Weisbrod, T., Wirz, B., Wostl,
W. (1994) Large scale preparation of chiral building blocks for the P 3 site of renin inhibitors,
Bioorg. Med. Chem. 2, 403–410
● Wirz, B., Weisbrod, T., Estermann, H. (1995) Enzymatic reactions in process research – The
importance of parameter optimization and workup, Chimica Oggi. 14, 37–41
366
O
O
N
H
N NH
2
OH
OH