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Document Page 210 34. Ghosh D, Wawrzak Z, Weeks CM, Duax WL, Erman M. The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in chart-chain dehydrogenases. Structure 2; 1994:629–640. 35. Dessen A, Quemard A, Blanchard JS, Jacobs Jr, WR, Sacchettini JC. Crystal structure and function of the isoniazid target for Mycobacterium tuberculosis. Science 267; 1995:1638–1641. 36. Rafferty JB, Simon JW, Baldock C, Artymiuk PJ, Stuitje AR, Slabas AR, Rice DW. Common themes in redox chemistry emerge from the X-ray structure of oilseed rape, Brassica napus, enoyl acyl carrier protein reductase. Structure 3; 1995:927–938. 37. Tanaka N, Nonaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 Å resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family. Structure 4; 1996:33–45. 38. Tsigelny I, Baker ME. Structures stabilizing the dimer interface on human 11β-hydroxysteroid dehydrogenase-types 1 and 2 and human 15-hydroxyprostaglandin dehydrogenase and their homologs. Biochem Biophys Res Commun 217; 1995:859–868. 39. Tsigelny I, Baker ME. Structures important in mammalian 11β-and 17β-hydroxysteroid dehydrogenases. J Ster Biochem Molec Biol 55; 1995:589–600. 40. Obeid J, White PC. Tyr-179 and lys-183 are essential for enzymatic activity of 11β-hydroxysteroid dehydrogenase. Biochem Biophys Res Comm 188; 1992:222–227. 41. Puranen TJ, Poutanen MH, Peltoketo HE, Vihko PT, Vihko RK. Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1. Biochem J 304; 1994:289–293. 42. Chen Z, Lu L, Shirley M, Lee WR, Chang SH. Site-directed mutagenesis of glycine-14 and two “critical” cysteinyl residues in Drosophila alcohol dehydrogenase. Biochemistry 29; 1990:1112–1118. 43. Chen Z, Lin Z-G, Lee WR, Chang SH. Role of aspartic acid-38 in the cofactor specificity of Drosophila alcohol dehydrogenase. Eur J Biochem 202; 1991:263–267. 44. Chen Z, Jiang JC, Lin Z-G, Lee WR, Baker ME, Chang SH. Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. Biochemistry 32; 1993:3342–3346. 45. Cols N, Marfany G, Atrian S, Gonzalez-Duarte R. Effect of site-directed mutagenesis on conserved positions of Drosophila alcohol dehydrogenase. FEBS Lett 319; 1993:90–94. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_210.html (1 of 2) [4/5/2004 5:06:33 PM]
Document 46. Ribas dePoplana L, Fothergill-Gilmore LA. The active site architecture of a short chain dehydrogenase defined by site-directed mutagenesis and structure modeling. Biochemistry 33; 1994:7047–7055. 47. Chen Z, Tsigelny I, Lee WR, Baker ME, Chang SH. Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP +. FEBS Lett 356; 1994:81–85. 48. Chenevert S, Fossett N, Lee WR, Tsigelny I, Baker ME, Chang SH. Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. Biochem J 308; 1995:419–423. 49. Chothia C, Lesk AM. The relation between the divergence of sequence and structure in proteins. EMBO J 5; 1986:823–826. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_210.html (2 of 2) [4/5/2004 5:06:33 PM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document dine (3TC), and 2',3'-dide
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Document Analysis of various HIV-1
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Document Table 3 HIV-1 RT Amino Aci
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document receptor, it has not yet b
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Document Figure 6 Rat and human B2
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Page 281 and 282: Document 9 Structural Studies of Al
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Document Cyclotheonamide A (CtA), a
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Document Table 2 Naturally Occurrin
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Document 12 Polypeptide Modulators
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Document C. Specificity Figure 4 Th
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Document 17. Szelke M. Chemistry of
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Document 16 Progress in the Design
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document Figure 11 Functional resid
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Document Figure 13 The identified p
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Document B. Interleukin-1 Receptor
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Document Page 425 Antinflammatory D
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Document Page 427 These aromatic di
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Document 5. Dinarello CA. On the Bi
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Document 21. Seckinger P, Lowenthal
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Document 39. Saurat JH, Schfferli J
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Document 74. Bender PE, Lee JC., ed
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Document 102. Machin PJ, Osbond JM,
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Page 443 that allowed for
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Document Figure 4 Stereo view of IF
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Document Figure 5 Velcro-key model
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Document Figure 6 Proposed receptor
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Document Page 451 with the cytoplas
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Document for directed subcellular t
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Document Page 462 strains of influe
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Document Figure 3 (a) A MOLSCRIPT [
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Document B. Protein Structure Page
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Document Figure 5 (a) Stereo image
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document Figure 8 Stereo image of t
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Document Page 476 nM, respectively.
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Document Page 478 lished—was asso
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 40. Drzenick R, Frank H, R
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 486 95. Ryan DM, Tice
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Figure 7 HRV14 VP1 hydroph
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Document C. Structure-Activity Rela
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Document Page 514 sis. Large number
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Document conformational transition
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Document Page 518 The differences b
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Document 10. Mast EE, Harmon MW, Gr
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Document 21 Structure-Based Combina
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Document Page 545 protein binding s
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Document Page 555 N-acylpyrrolidine
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Document 10. Bobbyer DNA, Goodford
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Document 30. O'Shea EK, Rutkowski R
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Document 22 Peptidomimetic and Nonp
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Document 12640-0567a.gif Figure 6 C
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Document Figure 22 Protease 3D stru
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Document Page 601 inhibitors 100 [1
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Document Page 603 hydroxymethyl sub
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Document Figure 32 PTP and PTB 3D s
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document Page 623 53. Bird J, Harpe
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Document 78. Rodriguez M, Crosby R,
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Document MA, Welch KM, Hallak H, Ta
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Document Page 626 SJ, Ogden RC, Red
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document 236. (a) Marshall MS. TIBS
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Document 274. (a) Kavanaugh WM, Wil
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Document replacements, 563-565 1-am
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Document inhibitor binding, 323, 33
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Document site, 52, 55, 61 triad, 24
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document overview, 103-104, 108-109
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Document [Inhibitors] 2-((3,4-dihyd
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Document antagonistic activity, 416
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Document [Interleukin-1] homology w
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Document Kininogen, 119 high molecu
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Document Matrix-metalloproteinase (
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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