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Document Page 519 From the animal and human experiments it is clear that the cure for some common colds is within reach. These therapies are also quite likely to be efficacious in enteroviral diseases, for example in cardiogenic coxsackie virus infection [97]. Acknowledgments We would like to acknowledge that there have probably been hundreds of people who have contributed to work reviewed here. We would like especially to thank the many people at ViroPharma, Sterling Winthrop, Purdue University, and the University of Wisconsin at Madison with whom we have worked over the years. We would also like to thank Dirksen Bussiere and Yvonne Martin for reading and editing this manuscript prior to submission. References 1. Rueckert RR. Picornaviridae and their replication. In: Fields BN, Knipe DM, eds. Virology. New York: Raven Press, 1990:507–548. 2. Sperber SJ, Hayden FG. Chemotherapy of rhinovirus colds. Antimicrob Agents Chemother 1988; 32:409–419. 3. Uncapher CR, DeWitt CM, Colonno RJ. The major and minor group receptor families contain all but one human rhinovirus serotype. Virology 1991; 180:814–817. 4. Hamparian VV, Colonno RJ, Cooney MK, et al. A collaboration report: rhinoviruses—extension of the numbering system from 89 to 100. Virology 1987; 159:191–192. 5. Muckelbauer JK, Kremer MK, Minor I, et al. The structure of coxsackievirus B3 at 3.5 Å resolution. <strong>Structure</strong> 1995; 3:653–667. 6. Schiff GM, Sherwood JR, Young EC, Mason JL, Gamble JN. Prophylactic efficacy of WIN 54954 in prevention of experimental human coxsackie A21 infection and illness. Antivir Res 1992; 17 (Suppl 1):92. 7. Andries K, Dewindt B, Snoeks J, et al. Two groups of rhinoviruses revealed <strong>by</strong> a panel of antiviral compounds present sequence divergence and differential pathogenicity. J Virol 1990; 64(3):1117–1123. 8. Flower RJ, Moncada S, Vane Jr. The pharmacologic basis of therapeutics. In: Gilman AG, Goodman LS, Gilman A, eds. Analgesic-antipyretics and anti-inflammatory agents; drugs employed in the treatment of gout. New York: Macmillan, 1080:682–728. 9. Drake JW. Rates of spontaneous mutation among RNA viruses. Proc Natl Acad Sci USA 1993; 90(9):4171–4175. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_519.html (1 of 2) [4/9/2004 12:45:52 AM]
Document 10. Mast EE, Harmon MW, Gravenstein S, et al. Emergence and possible transmission of amantadineresistant viruses during nursing home outbreaks of influenza A (H3N2). Am J Epidem 1991; 134(9):988–997. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_519.html (2 of 2) [4/9/2004 12:45:52 AM]
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Structure-based Drug Design 14 Stru
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Page 685 and 686: Document Lists of Bonding Fragment
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Document D ddI, 152 tumour necrosis
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Document [Protease targets] serinyl
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