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KD eds. Peptides: <strong>Structure</strong> and Function. Rockford:Pierce Chemical Company, 1985:759–762.<br />

22. Rich DH, Sun ETO, Ulm E. Synthesis of analogues of the carboxyl proteinase inhibitor pepstatin.<br />

Effect of structure on the inhibition of pepsin and renin. J Med Chem 1980; 23:27–33.<br />

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diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of<br />

inhibitor binding and description of the rigid body shifts in the enzyme. EMBO J 1989; 8:2179–2188.<br />

24. Iizuka K, Kamijo T, Kubota T, Akahane K, Umeyama H, Kiso Y. New human renin inhibitors<br />

containing an unnatural amino acid, norstatine. J Med Chem 1988; 31:701–704.<br />

25. Dann JG, Stammers DK, Harris, CJ, Arrowsmith RJ, Davies DE, Hardy GW, Morton JA. Human<br />

renin: an new class of inhibitors. Biochem Biophys Res Commun 1986; 134:71–77.<br />

26. Cooper JB, Foundling SI, Blundell TL, Arrowsmith RJ, Harris CJ, Champness JN. A rational<br />

approach to the design of antihypertensives: X-ray studies of complexes between aspartic proteinases<br />

and aminoalcohol inhibitors. In: Leeming PR, ed. Topics in Medicinal Chemistry. London: Royal<br />

Society of Chemistry, 1988; 308–313.<br />

27. Lunney EA, Hamilton HW, Hodges JC, Kaltenbrohn JS, Repine JT, Badasso M, Cooper J, Dealwis<br />

C, Wallace B, Lowther WT, Dunn BM, Humblet C. Analyses of ligand binding in five endothiapepsin<br />

crystal complexes and their use in the design and evaluation of novel renin inhibitors. J Med Chem<br />

1993; 36:3809–3820.<br />

28. Bartlett PA, Kezer WB. Phosphinic acid dipeptide analogues: potent, slowbinding inhibitors of<br />

aspartic proteinases. J Amer Chem Soc 1984; 106:4282–4283.<br />

29. Greenlee WJ. Renin inhibitors. Pharm Res 1987; 4(5):364–374.<br />

30. Thaisrivongs S, Pals DT, Harris DW, Kati WM, Turner SR. <strong>Design</strong> and synthesis of potent and<br />

specific renin inhibitors containing difluorostatine, difluorostatone and related analogues. J Med Chem<br />

1986; 29:2088–2093.<br />

31. Veerapandian B, Cooper JB, Sali A, Blundell TL. Direct observation <strong>by</strong> X-ray analysis of the<br />

tetrahedral “intermediate” of aspartic proteinases. Protein Science 1992; 1:322–328.<br />

32. Suguna K, Padlan EA, Smith CW, Carlson WD, Davies DR. Binding of a reduced peptide inhibitor<br />

to the aspartic proteinase from Rhizopus chinensis: implications for a mechanism of action. Proc Natl<br />

Acad Sci USA 1987; 84:7009–7013.<br />

33. Ptitsyn OB. Pure Appl Chem 1973; 31:227–244.<br />

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