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Document Page 522 49. Roivainen M, Piirainen L, Rysa T, Narvanen A, Hovi T. An immunodominant N-terminal region of VP1 protein of poliovirion that is buried in the crystal structure can be exposed in solution. Virology 1993; 195:762–765. 50. Yafal AG, Kaplan G, Racaniello VR, Hogle JM. Characterization of poliovirus conformational alteration mediated by soluble cell receptors. Virology 1993; 197:501–505. 51. Stroud R. Ion channel forming colicins. Curr Opin Struc Biol 1995; 5:514–520. 52. McSharry JJ, Caliguiri LA, Eggers HJ. Inhibition of uncoating of poliovirus by arildone, a new antiviral drug. Virology 1979; 97:307–315. 53. Abel MD, Cameron AD, Ha CM, et al. Novel azoylalkyloxy compounds with antipicornaviral activity. Antivir Chem Chemother 1995; 6(4):245–254. 54. Diana GD, Cutcliffe D, Volkots DL, et al. Antipicornavirus activity of tetrazole analogues related to disoxaril. J Med Chem 1993; 36(22):3240–3250. 55. Giranda VL, Russo GR, Felock PJ, et al. The structures of four methyltetrazole-containing compounds in human rhinovirus serotype 14. Acta Cryst D 1995; D51:496–503. 56. Kim KH, Willingman P, Gong ZX, et al. A comparison of the anti-rhinoviral drug binding pocket in HRV14 and HRV1A. J Mol Biol 1993; 230:206–227. 57. Andries K, DeWindt B, Snoeks J, Willebrords R, VanEemeren K. Anthirhinovirus spectrum and mechanism of action of R77975. Antivir Res 1991; 1 Suppl:98. 58. Chapman MS, Minor I, Rossmann MG, Diana GD, Andries K. Human rhinovirus 14 complexed with antiviral compound R 61837. J Mol Biol 1991; 217:455–463. 59. Moeremans M, Raermaeker M, Daneels G, et al. Study of the binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound. Antimicrob Agents Chemother 1992; 36(2):417–424. 60. Tisdale M, Selway JWT. Effect of dichloroflavan (BW683C) on the stability and uncoating of rhinovirus type 1B. Antimicrob Chemother 1984; 14(Suppl A):97–105. 61. Ash RJ, Parker RA, Hagan AC, Mayer GD. RMI 15,731 (1-[5-tetradecyloxy-2-furanyl]ethanone), a new antirhinovirus compound. Antimicrob Agents Chemother 1979; 16:301–305. 62. Zhang AQ, Nanni RG, Li T, et al. Structure determination of antiviral compound SCH-38057 complexed with human rhinovirus-14. J Mol Biol 1993; 230(3):857–867. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_522.html (1 of 2) [4/9/2004 12:46:14 AM]
Document 63. Rozhon E, Cox S, Buontempo P, et al. SCH-38057—a picornavirus capsid-binding molecule with antiviral activity after the initial stage of viral uncoating. Antivir Res 1993; 21(1):15–35. 64. Ishitsuka H, Ninomiya YT, Ohsawa C, Fujiu M, Suhara Y. Direct and specific inactivation of rhinovirus by chalcone Ro 09-0410. Antimicrob Agents Chemother 1982; 22(4):617–621. 65. Yasin SR, al-Nakib W, Tyrrell AJ. Pathogenicity for humans of human rhinovirus type 2 mutants resistant to or dependent on chalcone Ro 09–0410. Antimicrob Agents Chemother 1990; 34:963–966. 66. Ninomiya Y, Shimma N, Ishitsuka H. Comparative studies on the antirhinovirus activity and mode of action of the rhinovirus capsid binding agents, chalcone amides. Antivir Res 1990; 13:61–74. 67. Kenny MT, Dulworth JK, Bargar TM, Torney HL, Graham MC, Manelli AM. In vitro antipicornavirus activity of the 6-substituted 2-(3',4'-dichlorophenoxy)-2H- http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_522.html (2 of 2) [4/9/2004 12:46:14 AM]
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Structure-based Drug Design 14 Stru
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Document 60. Condra JH, Schleif WA,
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Document 74. Reddy RM, Varney MD, K
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Document 2 Structural Studies of HI
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Document dine (3TC), and 2',3'-dide
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Document monophosphate analogs whic
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Document Analysis of various HIV-1
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Document Page 54 Table 2) [12,54].
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Document Page 56 It is also attract
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 61 now clear that the
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Document Page 65 cal properties of
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Document Page 67 Biochemical data s
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Document Page 69 determining the me
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 30. Coffin JM. HIV populat
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Document 45. Majumadar C, Abbotts J
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Document reverse transcriptase inhi
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Document 75. Ring CS, Sun E, McKerr
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Document 89. Hughes SH, Arnold E, H
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Figure 1 Retroviral lifecy
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Document Figure 2 In vivo reactions
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Document Page 88 transfer (Figure 3
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Document Page 92 The role of the N-
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Document Figure 6 Molscript stereo
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Document Page 96 region in the HIV-
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Document day junction resolving enz
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Document -62° for HIV-1 integrase,
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Document Page 101 crystallized unde
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Document Figure 8 Molscript stereo
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Document proposed mechanisms. For e
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 65. Gallay P, Swingler S,
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 125 binding site on t
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Document Page 127 The des-Arg 9 for
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Document Page 129 tolerated by the
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Document receptor, it has not yet b
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Document Page 133 This initial stag
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Document Page 135 might be jointly
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document 16. Martorana PA, Kettenba
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Document 39. Mavunkel BJ, Lu Z, Kyl
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Figure 5 (a) A cut away vi
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Document Page 182 (SAR) model. The
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Document IX. S2' Interactions Page
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Document Figure 6 (a) The pocket of
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Document 7 Structure—Function Rel
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Document Page 207 sure and the acti
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Document Cyclotheonamide A (CtA), a
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Document 16 Progress in the Design
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Document Page 398 with growth hormo
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Document Figure 11 Functional resid
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Document Figure 13 The identified p
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Document B. Interleukin-1 Receptor
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Document Page 425 Antinflammatory D
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Document 39. Saurat JH, Schfferli J
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Figure 4 Stereo view of IF
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Document Figure 5 Velcro-key model
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Document Page 451 with the cytoplas
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Document Page 462 strains of influe
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Document Figure 3 (a) A MOLSCRIPT [
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Document B. Protein Structure Page
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Document Figure 5 (a) Stereo image
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document Figure 8 Stereo image of t
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Document Page 476 nM, respectively.
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Page 601 and 602: Document 64. Ward CW, Elleman TC, A
Page 603 and 604: Document 80. Suzuki Y, Sato K, Kiso
Page 605 and 606: Document Page 486 95. Ryan DM, Tice
Page 607 and 608: Document Page 488 against most of t
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Page 611 and 612: Document A. The Canyon Page 491 The
Page 613 and 614: Document Subsequent studies have sh
Page 615 and 616: Document Page 495 of the RNA and pr
Page 617 and 618: Document Figure 4 A ribbon diagram
Page 619 and 620: Document Figure 5 Some compounds wh
Page 621 and 622: Document Figure 7 HRV14 VP1 hydroph
Page 623 and 624: Document C. Structure-Activity Rela
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Page 639 and 640: Document conformational transition
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Page 665 and 666: Document Page 535 by factoring in a
Page 667 and 668: Document Page 537 ries, holds the p
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Page 685 and 686: Document Lists of Bonding Fragment
Page 687 and 688: Document Figure 8 Minimized structu
Page 689 and 690: Document Page 555 N-acylpyrrolidine
Page 691 and 692: Document 10. Bobbyer DNA, Goodford
Page 693 and 694: Document structure. 2. Ligand probe
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Page 697 and 698: Document 22 Peptidomimetic and Nonp
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Document Figure 32 PTP and PTB 3D s
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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