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Document Figure 2 Panels (a), (b), and (c) depict VP1, VP2, and VP3 β barrels, respectively. In all cases the view is such that the virion exterior would be on the right side of the page. A capsid-binding compound is depicted as gray spheres as it is found inside VP1. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_492.html (1 of 2) [4/9/2004 12:34:08 AM] Page 492
Document Subsequent studies have shown this pocket is present in every known HRV and enterovirus structure. Page 493 This pocket is inside the β barrel of VP1, directly underneath the canyon floor where ICAM-1 binds (Figure 1c). The proximity of the hydrophobic drug-binding site to the receptor-binding site explains the effects these compounds have on viral attachment in specific HRV serotypes (see below). C. The β Cylinder The β cylinder is a complicated structure that lies on the inside of the viral coat (Figure 1c). There is one β cylinder at each icosahedral five-fold axis. The β cylinder is formed <strong>by</strong> winding the five-fold related VP3 N-termini around the symmetry axis. In close association with this cylinder is the N-terminal regions of VP1 and VP4. The myristoyl moiety attached to VP4 is observed in the poliovirus structures. This moiety is in close association with the cylinder formed <strong>by</strong> VP3 [19]. In HRVs, density consistent with the myristoyl moiety is also seen near the β cylinder [25]. In the HRVs, structural disorder of the first 25–28 Nterminal residues of VP4 obscures the connection between VP4 and the myristoyl group. The addition of myristic acid to protein is seen in many viral and cellular http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_493.html [4/9/2004 12:34:17 AM]
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netLibrary - eBook Summary Universi
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document dine (3TC), and 2',3'-dide
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Document Analysis of various HIV-1
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Document Page 54 Table 2) [12,54].
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 67 Biochemical data s
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 30. Coffin JM. HIV populat
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 106 on the same ring
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Page 589 and 590: Document Page 476 nM, respectively.
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Page 593 and 594: Document VI. Conclusion Page 480 It
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Page 617 and 618: Document Figure 4 A ribbon diagram
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