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Document 7. Ennis FA, Meager A. Immune interferon produced to high levels antigenic stimulation of human lymphocytes with influenza virus. J Exp Med 1981; 154:1279–1289. Page 481 8. Sprenger MJW, Beyer WEP, Kempen BM, Mulder PGH, Masurel N. Risk factors for influenza mortality. In: Hannoun C, et al. eds. Options for the Control of Influenza Virus II. Amsterdam: Excerpta Medica, 1993:15–23. 9. Smith FI, Palase P. Variation in influenza virus genes. Epidemiological, pathogenic, and evolutionary consequences. In: Krug RM, ed. The Influenza Viruses. New York: Plenum, 1989:319–359. 10. Skehel JJ. The origin of pandemic influenza virus. Symp Soc Gen Microbiol 1974; 24:321–342. 11. Webster RG, Laver WG. Antigenic variation in influenza viruses. In: Kilbourne ED, ed. Influenza Virus and Influenza. New York: Academic, 1975:269–314. 12. Smith W, Andrewes CH, Laidlaw PP. A virus obtained form influenza patients. Lancet 1933; 2:66–68. 13. Beveridge WI. Influenza: the last great plague. London: Heinemann, 1977. 14. Daniels RS, Downie JC, Hay AJ, Knossow M, Skehel JJ, Wang ML, Wiley DC. Fusion mutants of the influenza virus haemagglutinin glycoprotein. Cell 1985; 40:431–439. 15. Hay AJ, Thompson CA, Geraghty A, Hayhurst S, Grambas S, Bennett MS. The role of the M2 protein in influenza virus infection. In: Hannoun C, et al. eds. Options for the Control of Influenza Virus II. Amsterdam: Excerpta Medica, 1993:281–288. 16. Pinto LH, Holsinger LJ, Lamb RA, Influenza virus M2 protein has ion channel activity. Cell 1992; 69:517–528. 17. Hayden FG. Update on antiviral agents and viral drig resistance. In: Mandell GL, Douglas RG, Bennett JE, eds. Principles and Practice of Infectious Disease. Vol. 2. 2d ed. New York: Churchill Livingston. 1993:3–15. 18. Tyrrell DAJ. Influenza vaccines. Phil Trans R Soc Lond 1980; B288:449–460. 19. Fox JP, Cooney MK, Hall CE, Foy HM. Influenza virus infections in Seattle families, 1975–1979. II. Pattern of infection of invaded households and relation of age and prior antibody to occurrence of infection <strong>by</strong> time and age. Am J Epidemiol 1982; 116:228–242. 20. Chakraverty et al. Influenza Activity—United States and worldwide, and composition of the 1993–94 influenza vaccine. JAMA 1993; 269:1778–1779. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_481.html (1 of 2) [4/9/2004 12:28:23 AM]
Document 21. Both GW, Sleigh MJ, Cox NJ, Kendal AP. Antigenic drift in influenza virus H3 haemagglutinin from 1968 to 1980: multiple evolutionary pathways and sequential amino acid changes at key antigenic sites. J Virol 1983; 48:52–60. 22. Donnelly JJ, Friedman A, Martinez D, Montgomery DL, Shiver JW, Motzel SL, Ulmer JB, Liu MA. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. Nature Med 1995; 1:583–586. 23. Hirst GK. Adsorption of influenza hemagglutinins and virus <strong>by</strong> red blood cells. J Exp Med 1942; 76:1740–1743. 24. Colman PM, Influenza virus neuraminidase: Krug RM, ed. Enzyme and antigen. In: The Influenza Viruses. New York: Plenum, 1989:175–218. 25. Colman PM. Influenza virus neuraminidase: structure, antibodies, and inhibitors. Protein Science 1994; 3:1687–1696. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_481.html (2 of 2) [4/9/2004 12:28:23 AM]
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Structure-based Drug Design 14 Stru
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Document Page 108 mulate during tre
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Page 557 and 558: Document Figure 6 Proposed receptor
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Page 579 and 580: Document B. Protein Structure Page
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Page 583 and 584: Document Page 471 molecules in the
Page 585 and 586: Document hydroxy, and 6 Neu5Ac2en -
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Page 589 and 590: Document Page 476 nM, respectively.
Page 591 and 592: Document Page 478 lished—was asso
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Page 601 and 602: Document 64. Ward CW, Elleman TC, A
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Page 611 and 612: Document A. The Canyon Page 491 The
Page 613 and 614: Document Subsequent studies have sh
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Page 617 and 618: Document Figure 4 A ribbon diagram
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Document D ddI, 152 tumour necrosis
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Document [Protease targets] serinyl
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