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Document Page 391 36. Kuriyan J, Kong XP, Krishan TS, Sweet RM, Murgolo NJ, Field H, Cerami A, Henderson GB. Xray structure of trypanothione reductase from Crithidia fasciculata at 2.4 Å resolution. Proc Natl Acad Sci USA 1991; 88:8764–8768. 37. Hunter WN, Bailey S, Habash J, Harrop SJ, Helliwell JR, Aboagye-Kwarteng T, Smith K, Fairlamb AH. Active site of trypanothione reductase. A target for rational drug design. J Mol Biol 1992; 227:322–333. 38. Eads JC, Scapin G, Xu Y, Grubmeyer C, Sacchettini JC. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP. Cell 1994; 78:325–334. 39. Freymann D, Down J, Carrington M, Roditi I, Turner M, Wiley D. 2.9 Å resolution structure of the N-terminal domain of a Variant Surface Glycoprotein from Trypanosoma brucei. J Mol Biol 1990; 216:141–60. 40. Izzo P, Constanzo P, Luppo A, Rippa E, Paolella G, Salvatore F. Human aldolase A gene. Structural organization and tissue-specific expression <strong>by</strong> multiple promotors and alternate mRNA processing. Eur J Biochem 1988; 174:569–578. 41. Paolella G, Santamaria R, Izzo P, Constanzo P, Salvatore F. Isolation and nucleotide sequence of a full-length c-DNA coding for aldolase B from human liver. Nucl Acids Res 1984; 12:7401–7410. 42. Rottmann WH, Deselms KR, Niclas J, Camerato T, Holman PS, Green CJ, Tolan DR. The complete amino acid sequence of the human aldolase C isozyme drived from genomic clones. Biochim 1987; 69:137–145. 43. Grant PT, Sargent JR. Properties of L-α-glycerophosphate oxidase and its role in the respiration of Trypanosoma rhodesiense. Biochem J 1960; 76:229–237. 44. Clarkson AB, Brohn FH. Trypanosomiasis: an approach to chemotherapy <strong>by</strong> the inhibition of carbohydrate metabolism. Science 1976; 194:204–206. 45. Fairlamb AH, Opperdoes FR, Borst P. New approach to screening drugs for activity against African trypanosomes. Nature 1977; 265:270–271. 46. Evans DA, Brightman CJ, Holland MF. Salicylhydroxamic acid/glycerol in experimental trypanosomiasis. Lancet 1977; 769. 47. Van Der Meer C, Versluijs-Broers JAM, Opperdoes FR. Trypanosoma brucei: trypanocidal effect of salicylhydroxamic acid plus glycerol in infected rats. Exp Parasitol 1979; 48:126–134. 48. Opperdoes FR, Borst P. Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome. FEBS Létt 1977; 80:360–364. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_391.html (1 of 2) [4/5/2004 5:43:14 PM]
Document 49. Michels PAM, Hannaert V. The evolution of kinetoplastid glycosomes. J Bioenerg Biomembr 1994; 26:213–219. 50. Borchert TV, Pratt K, Zeelen JP, Callens M, Noble MEM, Opperdoes FR, Michels PAM, Wierenga RK. Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterization of a dimer-interface mutant. Eur J Biochem 1993; 211:703–710. 51. Verlinde CLMJ, Noble MEM, Kalk KH, Groendijk H, Wierenga RK, Hol WGJ. Anion binding at the active site of trypanosomal triosephosphate isomerase: monohydrogen phosphate does not mimic sulphate. Eur J Biochem 1991; 198:53– 57. 52. Noble MEM, Verlinde CLMJ, Groendijk H, Kalk KH, Wierenga RK, Hol WGJ. Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phospho-glycerate. J Med Chem 1991; 34:2709–2718. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_391.html (2 of 2) [4/5/2004 5:43:14 PM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 127 The des-Arg 9 for
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Document receptor, it has not yet b
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Document Page 133 This initial stag
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Page 176 0.43 Å) as the c
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Page 495 and 496: Document Page 398 with growth hormo
Page 497 and 498: Document All effects of the IL-1 fa
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Page 519 and 520: Document Figure 13 The identified p
Page 521 and 522: Document B. Interleukin-1 Receptor
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Page 527 and 528: Document Page 427 These aromatic di
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document Page 476 nM, respectively.
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Acknowledgments Page 620 I
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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