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Document 93. Woods JM, Bethell RC, Coates JAV, Healy N, Hiscox SA, Pearson BA, Ryan DM, Ticehurst J, Tilling J, Walcott SM, Penn CR. 4-Guanidino-2-4-Dideoxy-2,3-Dehydro-N-Acetylneuraminic Acid is a highly effective inhibitor both of the sialidase (Neuraminidase) and growth of a wide range of influenza A and B viruses In Vitro. Antimicro Agents and Chemotherapy 1993; 37:1473–1479. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_485.html (2 of 2) [4/9/2004 12:29:59 AM] 94. Luo M, Jedrzejas MJ, Singh S, White CL, Brouillette WJ, Air GM, Laver WG. Benzoic acid inhibitors of influenza virus neuraminidase. Acta Cryst 1995; D51:504–510.
Document Page 486 95. Ryan DM, Ticehurst J, Dempsey MH, Penn CR. Inhibition of influenza virus replication in mice <strong>by</strong> GG167 (40guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase. Antimicrob Chem Chemother 1994; 38(10),2270–2275. 96. Thomas GP, Forsyth M, Penn CR, McCauley JW. Inhibition of growth of influenza virus in vitro <strong>by</strong> 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid. Antiviral Res 1994; 24:351–356. 97. Hayden FG, Rollins BS, Madren LK. Anti-influenza activity of the neuraminidase inhibitor 4guanidino-Neu5Ac2en in cell culture and in human respiratory epithelium. Antiviral Res 1994; 25:123–131. 98. Hayden FG, Treanor JJ, Betts RF, Lobo M, Esinhart JD, Hussey EK. Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza, JAMA 1996; 275:295–299. 99. Nohle U, Beau J-M, Schauer R. Eur J Biochem 1982; 126:543–548. 100. Kimberlin DW, Crumpacker CS, Straus SE, Biron KK, Drew WL, Hayden FG, McKinlay M, Richman DD, Whitley RJ. Antiviral resistance in clinical practice. Antiviral Res 1995; 26:423–438. 101. Madren LK, Shipman C, Hayden FG. In vitro inhibitory effects of combinations of anti-influenza agents. Antiviral Chem Chemotherapy 1995; 6(2):109–113. 102. McKimm-Breschkin JL, Marshall D, Penn CR. Phenotypic changes observed in influenza viruses passaged in 4-amino or 4-guanidino-Neu5Ac2en in vitro. Abstracts, 9th Internat. Conf. on Negative Strand Viruses. Estoril, Portugal, 1994:260. 103. Gubareva LV, Bethell R, Hart GJ, Penn CR, Webster RG. Characterization of mutants of influenza virus selected with 4-guanidino-Neu5Ac2en. Abstracts, 14th Annual Meeting, Amer. Soc. for Virol. Austin, Texas, 1995:W44-1. 104. McKimm-Breschkin JL, Blick TJ, Sarasrabudhe AV, Tiong T, Marshall D, Hart GJ, Bethell RC, Penn CR. Generation and characterisation of variants of the NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en. Antimicrob Agents Chemotherapy 1995; in press. 105. Blick TJ, Tiong T, Sahasrabudhe A, Varghese JN, Colman PM, Hart GJ, Bethell RC, McKimm- Breschkin JL. Generation and characterization of an influenza virus variant with decreased sensitivity to the neuraminidase specific inhibitor 4-guanidino-Neu5Ac2en. Virology 1995; 214:475–484. 106. von Itzstein M, Wu W-Y, Jin B. The synthesis 2,3-didehydro-2,4-dideoxy-4-guanidiny-Nacetylneuraminic acid: a potent influenza virus inhibitor. Carbohydr Res 1994; 259:301–305. 107. Kraulis PJ. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Cryst 1991, D50:869–873. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_486.html (1 of 2) [4/9/2004 12:30:20 AM]
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Document 163. Lacey SF, Larder BA.
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Document [Protease targets] serinyl
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