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Document http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_221.html (1 of 2) [4/5/2004 5:07:18 PM] Page 221
Document Figure 3 (a) Ternary complex of MnATP with the inhibitor peptide PKI (5–24). Glu121 and Val123 of the conserved linker region of the protein kinase catalytic core form the bidentate hydrogen bond with the 6-amino group and N1 nitrogen of the purine base. Thr183, non-conserved, forms a hydrogen bond with the N7 position of purine. 2'-OH of ribose interacts with the side chain of Glu127 of helix D and P-3 Arg of the specific inhibitor while the 3'-OH interacts with Glu170 of the catalytic loop. (b) The local environment of serine nucleophile at P site (left site) and local environment of phosphorylated P site serine (right side). The side chain of the catalytic base is at hydrogen bond distance from-OH of the Ser nucleophile which defines the conserved substrate binding P site. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_221.html (2 of 2) [4/5/2004 5:07:18 PM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document dine (3TC), and 2',3'-dide
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Document Page 54 Table 2) [12,54].
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 67 Biochemical data s
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 45. Majumadar C, Abbotts J
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Document reverse transcriptase inhi
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Document 75. Ring CS, Sun E, McKerr
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Document 89. Hughes SH, Arnold E, H
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Figure 1 Retroviral lifecy
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Document Figure 2 In vivo reactions
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Document Figure 8 Molscript stereo
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document Page 115 21. Kulkosky J, J
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Document 65. Gallay P, Swingler S,
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 123 were poorly satis
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Document Page 125 binding site on t
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Document Page 127 The des-Arg 9 for
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Document receptor, it has not yet b
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Page 221 and 222: Document Page 182 (SAR) model. The
Page 223 and 224: Document IX. S2' Interactions Page
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Page 227 and 228: Document 5. Willenbrock F, Murphy G
Page 229 and 230: Document 20. Murphy G, Docherty AJP
Page 231 and 232: Document Page 189 36. Bode W, Reine
Page 233 and 234: Document 7 Structure—Function Rel
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Page 239 and 240: Document Figure 3 (Continued) Page
Page 241 and 242: Document Important for the validity
Page 243 and 244: Document Figure 4 Amino acids impor
Page 245 and 246: Document III. Results and Discussio
Page 247 and 248: Document Page 202 269, and valine-2
Page 249 and 250: Document Figure 6 Structure of α h
Page 251 and 252: Document Page 205 enzyme and of phe
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Page 257 and 258: Document 29. Baker ME. Genealogy of
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Page 263 and 264: Document Page 214 viruses. Specific
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Page 267 and 268: Document Page 218 The catalytic loo
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Page 275 and 276: Document protein kinase core is ess
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Page 281 and 282: Document 9 Structural Studies of Al
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Page 285 and 286: Document Figure 3 C α trace of the
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Page 289 and 290: Document Figure 5 Schematic represe
Page 291 and 292: Document Figure 7 Stereo of zopolre
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Page 301 and 302: Document 35. Pailhoux EA, Martinez
Page 303 and 304: Document 10 Structure-Based Design
Page 311 and 312: Document Cyclotheonamide A (CtA), a
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Document Figure 1 The coagulation c
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Document Table 2 Naturally Occurrin
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Document Table 3 Active Site Sequen
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Document Figure 5 Predicted seconda
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Document Lys in the P1 position is
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Document Page 276 In both cases the
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Document Figure 11 dArg-ATS 32-38 m
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Document C. Specificity Figure 4 Th
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Document 17. Szelke M. Chemistry of
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Document 34. Rosenberg SH, Plattner
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Document 16 Progress in the Design
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Document Table 1 Known Three-Dimens
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document Page 416 positions of the
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Document Figure 13 The identified p
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Document Page 425 Antinflammatory D
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Document 5. Dinarello CA. On the Bi
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Document 21. Seckinger P, Lowenthal
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Document 39. Saurat JH, Schfferli J
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Document 74. Bender PE, Lee JC., ed
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Document 102. Machin PJ, Osbond JM,
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document Page 441 sequence of the m
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Document Page 443 that allowed for
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Document Figure 5 Velcro-key model
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Document Page 451 with the cytoplas
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Document Page 462 strains of influe
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Document Figure 3 (a) A MOLSCRIPT [
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Document B. Protein Structure Page
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Document Figure 5 (a) Stereo image
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Document Page 471 molecules in the
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Document Figure 8 Stereo image of t
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Document Page 476 nM, respectively.
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Document Page 478 lished—was asso
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 40. Drzenick R, Frank H, R
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Figure 7 HRV14 VP1 hydroph
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Document C. Structure-Activity Rela
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Document Figure 9 A solvent-accessi
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Document Page 514 sis. Large number
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Document conformational transition
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Document Page 518 The differences b
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Document 81. Diana GD, McKinlay MA,
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Document 21 Structure-Based Combina
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Document Page 545 protein binding s
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Document Page 555 N-acylpyrrolidine
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Document 30. O'Shea EK, Rutkowski R
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Document B. Peptidomimetic Drugs: C
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Document 78. Rodriguez M, Crosby R,
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document 236. (a) Marshall MS. TIBS
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Document site, 52, 55, 61 triad, 24
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Kininogen, 119 high molecu
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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