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Document Figure 4 The information flow in a drug discovery process that connects elements of structure-based design and combinatorial chemistry for drug discovery. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_531.html (1 of 2) [4/9/2004 12:49:36 AM] Page 531
Document ciency of drug discovery (Figure 4). The process begins with the knowledge-based design of a library template or scaffold and involves the synthesis of small subsets of library members. As with structurebased design approaches, the process is an iterative one in which SAR data and structural data guide not only the iterative selection of library members for testing, but also the design of later generation library scaffolds. The integrated process is described in detail in the next few paragraphs. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_531.html (2 of 2) [4/9/2004 12:49:36 AM]
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Structure-based Drug Design 14 Stru
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Document References 1. Parks RE Jr.
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Document 6 Structural Implications
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Page 693 and 694: Document structure. 2. Ligand probe
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