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Document 5. National Advisory Eye Council (1994). In: Vision Research: A National Plan 1994–1998. National Institutes of Health Publication No. 93–3186. 6. Kador PF. The role of aldose reductase in the development of diabetic complications. Med Res Rev 1988; 8:325–352. Page 244 7. Dvornik D. Aldose Reductase Inhibition: An Approach to the Prevention of Diabetic Complications. New York: Biomedical Information Corporation 1987. 8. Dvornik D, Simard-Duquesne N, Krami M, Sestanj K, Gabbay KH, Kinoshita JN, Varma SD, Merola LO. Polyol accumulation in galatosemic and diabetic rats: control by an aldose reductase inhibitor. Science 1973; 182:1146–1148. 9. Sestanj K, Bellini F, Fung S, Abraham N, Treasurywala A, Humber L, Simard-Duquesne N, Dvornik D. N-[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]-N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor. J Med Chem 1984;27:255–256. 10. Ward WHJ, Sennitt CM, Ross H, Dingle A, Timms D, Mirrlees DJ, Tuffin DP. Ponalrestat: a potent and specific inhibitor of aldose reductase. Biochem Pharmacol 1990; 39:337–346. 11. Terashima H, Hama K, Yamamoto R, Tsuboshima M, Kikkawa R, Hatanaka 1, Shigeta Y. Effects of a new aldose reductase inhibitor on various tissues in vitro. J Pharmacol Exp. Ther 1984;229:226–230. 12. Peterson MJ, Sarges R, Aldinger CD. CP-45634: a novel aldose reductase inhibitor that inhibits polyol pathway activity in diabetic and galactosemic rats. Metabolism 1979; 28(supp 1):456–461. 13. Mylari BL, Larson ER, Beyer TA, Zembrowski WJ, Aldinger CE, Dee MF, Siegel TW, Singleton DH. Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2benzothiazolyl]methyl]-1-phthalazine-acetic acid (zopolrestat) and congeners. J Med Chem 1991; 34:108–122. 14. Srivastava SK, Petrash JM, Sadana AJ, Partridge CA. Susceptibility of aldose and aldehyde reductases to aldose reductase inhibitors. Curr Eye Res 1982; 2:407–410. 15. Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature 1992; 355:469–472. 16. Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 Å structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science 1992; 257:81–84. 17. Borhani DW, Harter TM, Petrash JM. The crystal structure of the aldose reductase-NADPH binary complex. J Biol Chem 1992; 267:24841–24847. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_244.html (1 of 2) [4/5/2004 5:09:29 PM]
Document 18. Wilson DK, Tarle I, Petrash JM, Quiocho FA. Refined 1.8 Å structure of human aldose reductase complexed with the potent inhibitor zopolrestat. Proc Natl Acad Sci USA 1993; 90:9847–9851. 19. Branden CI. The TIM barrel—the most frequently occurring folding motif in proteins. Curr Opin Struct Biol 1991; 1:978–983. 20. Feldman HB, Szczepanik PA, Havre P, Corrall RJM, Yu LC, Rodman HM, Rosner BA, Klein PD, Landau, BR. Stereospecificity of the hydrogen transfer catalyzd by human placental aldose reductase. Biochim Biophys Acta 1997; 480:14–20. 21. Wermuth B, Buergisser HB, Bohren KM, von Wartburg JP. Purification and characterization of human brain aldose reductase. Eur J Biochem 1982; 127:279–284. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_244.html (2 of 2) [4/5/2004 5:09:29 PM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Table 3 HIV-1 RT Amino Aci
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Document 106. Cirino NM, Cameron CE
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document 4 Bradykinin Receptor Anta
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Document receptor, it has not yet b
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Document We determined the structur
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Document large solvent channels and
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document B. Protein Structure Page
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Document 21. Both GW, Sleigh MJ, Co
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Document Page 488 against most of t
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Document Page 629 ML, Clare M, Decr
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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