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Document http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_556.html (3 of 3) [4/9/2004 12:53:38 AM] 12. Wade RC, Goodford PJ. Further development of hydrogen bond functions for use in determining energetically favorable binding sites on molecules of known
Document structure. 2. Ligand probe groups with the ability to form more than two hydrogen bonds. J Med Chem 1993; 36:148–156. Page 557 13. Rotstein SH, Murcko MA. GroupBuild: A fragment-based method for de novo drug design. J Med Chem 1993; 36:1700–1710. 14. Moon JB, Howe WJ. Computer design of bioactive molecules: a method for receptor-based de novo ligand design. Proteins: Structure, Function and Genetics 1991; 11:314–328. 15. Eisen MB, Wiley DC, Karplus M, Hubbard RE. HOOK: A program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site. Proteins: Structure, Function and Genetics 1994; 19:199–221. 16. Tschinke V, Cohen NC. The NEWLEAD program: a new method for the design of candidate structures from pharmacophoric hypotheses. J Med Chem 1993; 14:3863–3870. 17. Gillet VJ, Myatt G, Zsoldos Z, Johnson AP. SPROUT, HIPPO and CAESA: Tools for de novo structure generation and estimation of synthetic accessibility. Perspectives in Drug Discovery and Design 1995; 3:34–50. 18. Lewis RA, Roe DC, Huang C, Ferrin TE, Langridge R, Kuntz ID. Automated site-directed drug design using molecular lattices. J Mol Graphics 1992; 10:66–78. 19. Kuntz ID. Structure-based strategies for drug design and discovery. Science 1992; 257:1078–1082. 20. Caflisch A, Karplus M. Computational combinatorial chemistry for de novo ligand design: Review and assessment. Perspectives in Drug Discovery and Design 1995; 3:51–84. 21. Miranker A, Karplus M. Functionality maps of binding sites: a multiple copy simultaneous search method. Proteins: Structure, Function, and Genetics 1991; 11:29–34. 22. Caflisch A, Miranker A, Karplus M. Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase. J Med Chem 1993; 36:2142–2167. 23. Appelt K. Crystal structures of HIV-1 protease-inhibitor complexes. Perspectives in Drug Discovery and Design 1993; 1:23–48. 24. Wlodawer A, Erickson JW. Structure-based inhibitors of HIV-1 protease. Annu Rev Biochem 1993; 62:543–585. 25. Stubbs MT, Bode W. Crystal structures of thrombin and thrombin complexes as a framework for antithrombotic drug design. Perspectives in Drug Discovery and Design 1993; 1:431–452. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_557.html (1 of 2) [4/9/2004 12:53:41 AM]
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netLibrary - eBook Summary Universi
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document Table 3 HIV-1 RT Amino Aci
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Document Page 67 Biochemical data s
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 106. Cirino NM, Cameron CE
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document receptor, it has not yet b
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Document Page 135 might be jointly
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Document Figure 6 Rat and human B2
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document IV. Drug Design Progressio
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Document References 1. Parks RE Jr.
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Document 6 Structural Implications
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Document Important for the validity
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Document Page 202 269, and valine-2
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document A. The Canyon Page 491 The
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Document Page 495 of the RNA and pr
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Page 685 and 686: Document Lists of Bonding Fragment
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Page 689 and 690: Document Page 555 N-acylpyrrolidine
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Page 695 and 696: Document 30. O'Shea EK, Rutkowski R
Page 697 and 698: Document 22 Peptidomimetic and Nonp
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Document Figure 32 PTP and PTB 3D s
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document MA, Welch KM, Hallak H, Ta
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Document Page 626 SJ, Ogden RC, Red
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document inhibitor binding, 323, 33
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Document site, 52, 55, 61 triad, 24
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document overview, 103-104, 108-109
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Document antagonistic activity, 416
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Document Kininogen, 119 high molecu
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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