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Document Page 390 19. Byers TL, Castara P, Bitonti AJ. Uptake of the antitrypanosomal drug 5'-{[(Z)-4- amino-2butenyl]methylamino}-5'-deoxyadenosine (MDL 73811) by the purine transport system of Trypanosoma brucei brucei. Biochem J 1992; 283:755–758. 20. Schirmer RH, Müller JG, Krauth-Siegel RL. Disulfide-reductase inhibitors as chemotherapeutic agents: the design of drugs for trypanosomias is and malaria. Angew Chem Int Ed Engl 1995; 34:141–154. 21. Doering TL, Raper J, Buxbaum LU, Adams SP, Gordon JI, Hart GW, Englund PT. An analog of myristic acid with selective toxicity for African trypanosomes. Science 1991; 252:1851–1854. 22. Shaw PJ, Muirhead H. Crystallographic structure analysis of glucose-6-phosphate isomerase at 3.5 Å resolution. J Mol Biol 1977; 109:475–485. 23. Gamblin SJ, Muirhead H. Crystallographic structure analysis of glucose-6-phosphate isomerase at 3.5 Å resolution. J Mol Biol 1977; 109:475–485. 23. Gamblin SJ, Cooper B, Millar JR, Davies GJ, Littlechild JA, Watson HC. The crystal structure of human muscle aldolase at 3.0 Å resolution. FEBS Lett 1990; 262:282–286. 24. Wierenga RK, Noble MEM, Vriend G, Nauche S, Hol WGJ. Refined 1.83 Å structure of triosephosphate isomerase crystallized in the presence of 2.4 M ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase—glycerol-3-phosphate complex. J Mol Biol 1991; 220:995–1015. 25. Mande SC, Mainfroid V, Kalk KH, Goraj K, Martial JA, Hol WGJ. Crystal structure of recombinant human triosephosphate isomerase at 2.8 Å resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme. Protein Sci 1994; 3:810–821. 26. Vellieux FMD, Hajdu J, Verlinde CLMJ, Groendijk H, Read RJ, Greenhough TJ, Campbell JW, Kalk KH, Littlechild JA, Watson HC, Hol WGJ. Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data. Proc Natl Acad Sci USA 1993; 90:2355–2359. 27. Vellieux FMD, Hajdu J, Hol WGJ. Refined 3.2 Å structure of glycosomal holo glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei. Acta Cryst 1995; D 51:575–589. 28. Mercer WD, Winn SI, Watson HC. Twinning in crystals of human skeletal muscle D-glyceraldehyde- 3-phosphate dehydrogenase. J Mol Biol 1976; 104:277–283. 29. Read RJ, et al. Unpublished results. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_390.html (1 of 2) [4/5/2004 5:43:00 PM]
Document 30. Kim H, Feil I, Verlinde CLMJ, Petra PH, Hol WGJ. Crystal structure of glycosomal glyceraldehyde- 3-phosphate dehydrogenase from Leishmania mexicana: Implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochem 1995; 34:14975–14986. 31. Rice DW. The use of phase combination in the refinement of phosphoglycerate kinase at 2.5 Å resolution. Acta Cryst A 1981; 37:491–500. 32. Harlos K, Vas M, Blake CF. Crystal structure of the binary complex of pig muscle phosphogycerate kinase and its substrate 3-phospho-D-glycerate. Proteins: Struct Funct Genet 1992; 12:133–144. 33. Stuart DI, Levine M, Muirhead H, Stammers DK. Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å J Mol Biol 1979; 134:109–142. 34. Lantwin CB, Schlichting I, Kabsch W, Pai EF, Krauth-Siegel RL. The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADH reduced state. Proteins: Struct Funct Genet 1994; 18:161–173. 35. Karplus PA, Schulz GE. Refined structure of glutathione reductase at 1.54 Å resolution. J Mol Biol 1987; 195:701–729. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_390.html (2 of 2) [4/5/2004 5:43:00 PM]
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Document dine) and didanosine (dide
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document Table 1 Approval Indicatio
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Document [Protease targets] serinyl
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