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Document 77. Palase P, Schulman JL. Inhibitors of viral neuraminidase as potential antiviral drugs. In: Chemoprophylaxis and virus infections of the upper respiratory tract. vol. 1. Boca Raton, Florida: CRC Press, 1977:189–205. 78. Burmeister WP, Henrissat B, Bosso C, Cusack S, Ruigrok RWH. Influenza B virus neuraminidase can synthesize its own inhibitor. Structure 1993; 1:19–26. 79. Bossart-Whitaker P, Carson M, Babu YS, Smith CD, Laver WG, Air GM. Three dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-Nacetyl neuraminic acid. J Mol Biol 1993; 232:1069–1083. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_484.html (2 of 2) [4/9/2004 12:29:15 AM]
Document 80. Suzuki Y, Sato K, Kiso M, Hasegawa A. New ganglioside analogs that inhibit influenza virus sialidase. Glycoconjugate J 1990; 7:349–356. Page 485 81. Nagai T, Miyaichi Y, Tomimori T, Suzuki Y, Yamada H. Inhibition of influenza virus sialidase and anti-influenza virus activity by plant flavonoids. Chem Pharm Bull 1990; 38(5):1329–1332. 82. Nagai T, Yamada H. In vivo anti-influenza virus activity of Kampo (Japanese herbal) medicine “Shoseiryu-to” and its mode of action. Int J Immunopharmacol 1994; 16(8):605–613. 83. Miller CA, Wang P, Flashner M. Mechanism of Arthro-bacter sialophilus neuraminidase: the binding of substrates and transition state anologs. Biochem Biophys Res Commun 1978; 83:1479–1487. 84. Chong AKJ, Pegg MS, Taylor NR, von Itzstein M. Evidence for a sialyl cation transition state complex in the reaction of sialidase from influenza. Eur J Biochem 1992; 207:335–343. 85. Friebolin H, Brossmer R, Keilich G, Ziegler D, Supp M. 1H-NMR spektroskopischer nachweis der N-acetyl-a-D-neuraminsaure als primares spaltprodukt der neuraminidasen. Hoppe Seyler's Z Physiol Chem 1980; 361:697–702. 86. Lentz MR, Webster RG, Air GM. Site-directed mutation of the active site of influenza neuraminidase and implications for the catalytic mechanism. Biochemistry 1987; 26:5351–5358. 87. Chong AKJ, Pegg MS, von Itzstein M. Characterization of an ionisable group involved in the binding and catalysis by sialidase from influenza virus. Biochem Int 1991; 24:165–171. 88. Taylor NR, von Itzstein M. Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis. J Med Chem 1994; 37:616–624. 89. Janakiraman MN, White CL, Laver WG, Air MA, Luo M. Structure of influenza virus neuraminidase B/Lee/40 complexed with sialic acid and a dehydro anolog at 1.8A-resolution: implications for the catalytic mechanism. Biochem 1994; 33:8172–8179. 90. Goodford PJ. A computational procedure for determining energetically favorable binding sites on biologically important macromolecules. J Med Chem 1985; 28:849–857. 91. Von Itzstein M, Wu W-Y, Kok GB, Pegg MS, Dyson JC, Jin B, VanPhan T, Symthe ML, White HF, Oliver SW, Colman PM, Varghese JN, Ryan DM, Woods JM, Bethell R C, Hotham VJ, Cameron JM, Penn CR. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 1993; 363:418–423. 92. Pearlman DA, Case DA, Caldwell J, Seibel G, Singh UC, Weiner PK, Kollman PA. AMBER 4.0. San Francisco, California: University of California, 1990. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_485.html (1 of 2) [4/9/2004 12:29:59 AM]
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Structure-based Drug Design 14 Stru
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Document 74. Reddy RM, Varney MD, K
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document 4 Bradykinin Receptor Anta
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Document receptor, it has not yet b
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Document Figure 9 Composition of te
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Page 579 and 580: Document B. Protein Structure Page
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Page 583 and 584: Document Page 471 molecules in the
Page 585 and 586: Document hydroxy, and 6 Neu5Ac2en -
Page 587 and 588: Document Figure 8 Stereo image of t
Page 589 and 590: Document Page 476 nM, respectively.
Page 591 and 592: Document Page 478 lished—was asso
Page 593 and 594: Document VI. Conclusion Page 480 It
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Page 611 and 612: Document A. The Canyon Page 491 The
Page 613 and 614: Document Subsequent studies have sh
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Page 617 and 618: Document Figure 4 A ribbon diagram
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document [Protease targets] serinyl
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