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Document Page 319 63. Lampe RA, Lo MMS, Keith RA, Horn MB, McLane MW, Herman JL, Spreen RC. Effects of sitespecific acetylation on ω-conotoxin GVIA binding and function. Biochemistry 1993; 32:3255–3260. 64. Basus VJ, Nadasdi L, Ramachandran J, Miljanich GP. Solution structure of ω-conotoxin MVIIA using 2D NMR spectroscopy. FEBS Lett 1995; 370:163–169. 65. Manoleras N, Norton RS. Three-dimensional structure in solution of neurotoxin III from the sea anemone Anemonia sulcata. Biochemistry 1994; 33:11051–11061. 66. Stanfield RN, Wilson IA. Protein-peptide interactions. Curr Opinion Str Biol 1995; 5:103–113. 67. Stampe P, Kolmakova-Partensky L, Miller C. Intimations of K + channel structure from a complete functional map of the molecular surface of charybdotoxin. Biochemistry 1994; 33:443–450. 68. Goldstein SAN, Pheasant DJ, Miller DJ. The charybdotoxin receptor of a Shaker K + channel: peptide and channel residues mediating molecular recognition. Neuron 1994; 12:1377–1388. 69. Kim JI, Takahashi M, Ogura A, Kohno T, Kudo Y, Sato K. Hydroxyl group of Tyr 13 is essential for the activity of ω-conotoxin GVIA, a peptide toxin for N-type calcium channel. J Biol Chem 1994; 269:23876–23878. 70. Clackson T, Wells JA. A hot spot of binding energy in a hormone-receptor interface. Science 1995;267:383–386. 71. Jin L, Wells JA. Dissecting the energetics of an antibody-antigen interface <strong>by</strong> alanine shaving and molecular grafting. Protein Sci 1994; 3:2351–2357. 72. Marshall GR. A hierarchical approach to peptidomimetic design. Tetrahedron 1993; 49:3547–3558. 73. Chen S, Chrusciel RA, Nakanishi H, Raktabutr A, Johnson ME, Sato A, Wiener D, Hoxie J, Saragovi HU, Greene MI, Kahn M. <strong>Design</strong> and synthesis of a CD4 β-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes. Proc Natl Acad Sci USA 1992; 89:5872–5876. 74. Jackson S, De Grado W, Dwivedi A, Parthasarathy A, Higley A, Krywko J, Rock-well, A, Markwalder J, Wells G, Wexler R, Mousa S, Harlow R. Template-constrained cyclic peptides: design of high-affinity ligands for GPIIb/IIIa. J Am Chem Soc 1994; 116:3220–3230. 75. Ohlstein EH, Nambi P, Douglas SA, Edwards RM, Gellai M, Lago A, Leber JD, Cousins RD, Gao A, Frazee JS, Peishoff CE, Bean JW, Eggleston DS, Elshourbagy NA, Kumar C, Lee JA, Yue T-L, Louden C, Brooks DP, Weinstock J, Feuerstein G, Poste G, Ruffolo RR, Gleason JG, Elliot JD. SB 209670, a rationally designed potent nonpeptide endothelin receptor antagonist. Proc Natl Acad Sci USA 1994; 91:8052–8056. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_319.html (1 of 2) [4/5/2004 5:24:17 PM]
Document 76. Gould AR, Mabbutt BC, Llewellyn LE, Goss NH, Norton RS. Linear and cyclic peptide analogues of the polypeptide cardiac stimulant anthopleurin-A. 1H-NMR and biological activity studies. Eur J Biochem 1992; 206:641–651. 77. Stocker M, Miller C. Electrostatic distance geometry in a K + channel vestibule. Proc Natl Acad Sci USA 1994; 91:9509–9513. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_319.html (2 of 2) [4/5/2004 5:24:17 PM]
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Structure-based Drug Design 14 Stru
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Document 106. Cirino NM, Cameron CE
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document We determined the structur
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Page 415 and 416: Document 17. Szelke M. Chemistry of
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document Page 441 sequence of the m
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Document B. Protein Structure Page
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Document 21. Both GW, Sleigh MJ, Co
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Acknowledgments Page 620 I
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 631 197. Musil D, Zuc
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document [Protease targets] serinyl
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