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Document Table 2 Three-Dimensional <strong>Structure</strong> Studies of the IFNs Type of Study Reference X-ray studies IFN-β IFN-γ human IFN-γ bovine IFN-γ rabbit IFN-γ human + receptor NMR studies Models IFN-γ human IFN-γ mouse N-terminal peptide (1–39) IFN-α2a IFN-α8 IFN-τ sheep 2 3 C.T. Samudzi, J.R. Rubin, unpublished data 4 5 6 7 8 9 10 T. Senda, S.I. Saitoh, Y. Mitsui, J.Li, and R.M. Roberts, unpublished data Note: This is not meant to be an exhaustive list of all structural studies of the IFNs. It only highlights some of the three-dimensional studies that have been conducted. Page 439 While there are no hard-and-fast rules for conducting structure/function studies, the approaches taken for studying the IFNs can be used to illustrate some of the methods that have been successful. Over the years, a large body of work has accumulated on the IFNs, including a number of structural studies. Table 2 summarizes some of the studies exploring the three-dimensional structure of the IFNs. The following sections review some of the structure/function studies that have begun to elucidate important features of IFN activity and form a basis for future rational drug design. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_439.html (1 of 2) [4/9/2004 12:10:45 AM]
Document II. Type IFNs A great deal of structure/function analysis has been done on the Type I IFNs. One Type I IFN in particular, IFN-τ has received attention recently because of its lower cytotoxicity compared to the IFNαs. <strong>Structure</strong>/function studies have concentrated on comparing IFN-τ with IFN-α. Therefore, IFN-τ provides an excellent example of structure/function studies of the Type I IFNs. First isolated from the conceptuses of sheep, IFN-τ is the major conceptus secretory protein responsible for signaling maternal recognition of pregnancy in ruminants [11]. it is produced in large quantities (200 μg in 30 h from a day 16 conceptus culture). The protein was purified using a combination of anion exchange and molecular sieve chromatography. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_439.html (2 of 2) [4/9/2004 12:10:45 AM]
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