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Document Page 456 38. Lundell D, Lunn C, Dalgarno D, Fossetta J, Greenberg R, Reim R, Grace M, Narula S. The carboxylterminal region of human interferon-gamma is important for biological activity: mutagenic and NMR analysis. Prot Eng 1991; 4(3):335–341. 39. Zu X, Jay FT, The E 1 functional epitope of the human interferon-α is a nuclear targeting signal-like element. J Biol Chem 1991; 266:6023–6026. 40. Bader T, Wietzerbin J. Nuclear accumulation of interferon-gamma. Proc Natl Acad Sci USA 1994;91:11831–11835. 41. Van Volkenburg MA, Griggs ND, Jarpe MA, Pace JL, Russel SW, Johnson HM. Binding site on the murine interferon-gamma receptor for interferon-gamma has been identified using the synthetic peptide approach. J Immunol 1993; 151:6206– 6213. 42. Fernando LP, LeClaire RD, Obici S, Zavodny PJ, Russell SW, Pace JL. Stable expression of a secreted form of the mouse IFN-α receptor <strong>by</strong> rate cells. J Immunol 1991; 147:541–547. 43. Szente BE, Soos JM, Johnson HM. The C-terminus of IFN-α is sufficient for intracellular function. Biochem Biophys Res Comm 1994; 203:1645–1654. 44. Fidler IJ, Fogler WE, Kleinerman ES, Saiki I. Abrogation of species specificity for activation of tumoricidal properties in macrophages <strong>by</strong> a recombinant mouse or human interferon gamma encapsulated in liposomes. J Immunol 1985; 135:4289–4296. 45. Sancéau J, Sondermeyers P, Béranger F, Falcoff R, Vaquero C. Intracellular human interferon triggers an antiviral state in transformed murine L cells. Proc Natl Acad Sci USA 1987;84:2906–2910. 46. Smith MR, Muegge K, Keller JR, Kung HF, Young HA, Durum SK. Direct evidence for an intracellular role for interferon-gamma. J Immunol 1990; 144:1777–1782. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_456.html (1 of 2) [4/9/2004 12:12:24 AM]
Document 47. Igarashi K, Garotta G, Ozmen L, Ziemiecki A, Wilks AF, Harpur AG, Larner AC, Finbloom DS. Interferon gamma induces tyrosine phosphorylation of interferon gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptor. J Biol Chem 1994; 269:14333–14336. 48. Firmbach-Kraft I, Byers M, Shows T, Dalla-Favera R, Krolewski JJ. Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 1990; 5:1329–1336. 49. Bernards A. Predicted tyk2 protein contains two tandem protein kinase domains. Oncogene 1991; 6:1185–1187. 50. Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A. Two novel protein tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol Cell Biol 1991; 11:2057–2065. 51. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Silvennoinen O. Signaling through the hematopoietic cytokine receptors. Annu Rev Immunol 1995; 13:369–398. 52. Sakatsume M, Igarashi K-I, Winestock KD, Garotta G, Larner AC, Finbloom DS. The Jak Kinases differentially associate with the a and b (accessory factor) chains of the interferon-g receptor to form a functional receptor unit capable of activating STAT transcription factors. J Biol Chem 1995; 270:17528–17534. 53. Khurana Hershey GK, McCourt DW, Schreiber RD. Ligand-induced phosphorylation of the human interferong receptor. J Biol Chem 1990; 265:17868–17875. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_456.html (2 of 2) [4/9/2004 12:12:24 AM]
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Structure-based Drug Design 14 Stru
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Page 541 and 542: Document 17 Structure and Functiona
Page 543 and 544: Document Table 1 Approval Indicatio
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Page 585 and 586: Document hydroxy, and 6 Neu5Ac2en -
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Page 589 and 590: Document Page 476 nM, respectively.
Page 591 and 592: Document Page 478 lished—was asso
Page 593 and 594: Document VI. Conclusion Page 480 It
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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