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Document http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_546.html (1 of 2) [4/9/2004 12:51:45 AM] Page 546
Document Figure 2 Stereo view of the sixty propane minima (thick lines) obtained with the modified force field (see text) on the surface of the A peptide chain (medium lines) of the GCN4 leucine zipper (PDB code 2ZTA). Although the B peptide chain was removed during the MCSS procedure, its backbone and hydrophobic side chains are also drawn (thin lines) to show how the propane minima match the aliphatic groups of chain B. Hydrophobic residues are labeled at their C α atom.Five clusters of propane minima that do not match the hydrophobic side chain of the B helix involved in the interhelical interactions are labeled from A (top right) to E (bottom center) and discussed in the text. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_546.html (2 of 2) [4/9/2004 12:51:45 AM]
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Structure-based Drug Design 14 Stru
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Document IV. Drug Design Progressio
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Page 693 and 694: Document structure. 2. Ligand probe
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Document D ddI, 152 tumour necrosis
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