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Document 46. Pallaghy PK, Scanlon MJ, Monks SA, Norton RS. Three-dimensional structure in solution of the polypeptide cardiac stimulant anthopleurin-A. Biochemistry 1995; 34:3782–3794. 47. Monks SA, Pallaghy PK, Scanlon MJ, Norton RS. Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A. Structure 1995; 3:791–803. Page 318 48. Widmer H, Billeter M, W¨thrich K. The three-dimensional structure of the neurotoxin ATX Ia from Anemonia sulcata in aqueous solution by nuclear magnetic resonance spectroscopy. Proteins 1989; 6:357–371. 49. Fogh RH, Kem WR, Norton RS. Solution structure of neurotoxin I from the sea anemone Stichodactyla helianthus. A nuclear magnetic resonance, distance geometry and restrained molecular dynamics study. J Biol Chem 1990; 265:13016–13028. 50. Wilcox GR, Fogh RH, Norton RS. Refined structure in solution of the sea anemone neurotoxin Sh I. J Biol Chem 1993; 268:24707–24719. 51. Kraulis P. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr 1991; 24:946–950. 52. Scanlon MJ, Norton RS. Multiple conformations of the sea anemone polypeptide anthopleurin-A in solution. Protein Sci 1994; 3:1121–1124. 53. Khera PK, Benzinger GR, Lipkind G, Drum CL, Hanck DA, Blumenthal KM. Multiple cationic residues of anthopleurin-B that determine high affinity and channel isoform discrimination. Biochemistry 1995; 34:8533–8541. 54. Gould AR, Norton RS. Chemical modification of cationic groups in the polypeptide cardiac stimulant anthopleurin-A. Toxicon 1995; 33:187–199. 55. Pennington MW, Kem WR, Dunn BM. Synthesis and biological activity of six monosubstituted analogs of a sea anemone polypeptide neurotoxin. Peptide Res 1990; 3:228–232. 56. Gould AR, Mabbutt BC, Norton RS. Structure-function relationships in the polypeptide cardiac stimulant, anthopleurin-A. Effects of limited proteolysis by trypsin. Eur J Biochem 1990; 189:145–153. 57. Gooley PR, Blunt JW, Beress L, Norton RS. Effects of pH and temperature on cardioactive polypeptides from sea anemones: a 1H-NMR study. Biopolymers 1988; 27:1143–1157. 58. Sunahara S, Muramoto K, Tenma K, Kamiya H. Amino acid sequence of two sea anemone toxins from Anthopleura fuscoviridis. Toxicon 1987; 25:211–219. 59. Gallagher MJ, Blumenthal KM. Cloning and expression of wild-type and mutant forms of the cardiotonic polypeptide anthopleurin-B. J Biol Chem 1992; 267:13958–13963. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_318.html (1 of 2) [4/5/2004 5:24:15 PM]
Document 60. Pennington MW, Zadenberg I, Byrnes ME, Norton RS, Kem WR. Synthesis of the cardiac inotropic polypeptide anthopleurin-A. Intl J Pept Prot Res 1994; 43:463–470. 61. Gallagher MJ, Blumenthal KM. Importance of the unique cationic residues arginine-12 and lysine- 49 in the function of the cardiotonic polypeptide anthopleurin-B. J Biol Chem 1994; 269:254–259. 62. Khera PK, Blumenthal KM. Role of the cationic residues arginine-14 and lysine-48 in the function of the cardiotonic polypeptide anthopleurin-B. J Biol Chem 269:921–925. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_318.html (2 of 2) [4/5/2004 5:24:15 PM]
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Structure-based Drug Design 14 Stru
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Document Page 108 mulate during tre
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Page 415 and 416: Document 17. Szelke M. Chemistry of
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Page 421 and 422: Document Page 343 14 Structural Asp
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document Page 441 sequence of the m
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Document Acknowledgments Page 620 I
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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