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Document Imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. J Med Chem 1992; 35:847–858. 5. Weber PC, Wendoloski JJ, Pantoliano MW, Salemme FR. Crystallographic and thermodynamic comparison of natural and synthetic ligands bound to streptavidin. J Amer Chem Soc 1992; 114:3197–3200. 6. Weber PC, Pantoliano MW, Simons DM, Salemme FR. Structure-based design of synthetic azobenzene ligands for streptavidin. J Amer Chem Soc 1994; 116:2717–2724. 7. Andrews PR, Craik DJ, Martin JL. Functional group contributions to drug-receptor interactions. J Med Chem 1984; 27:1648–1657. Page 538 8. Terrett NK, Gardner M, Gordon DW, Kobylecki RJ, Steele J. Combinatorial synthesis—the design of compound libraries and their application to drug discovery. Tetrahedron 1995; 51:8135–8173. 9. Baum RM. Combinatorial approaches provide fresh leads for medicinal chemistry. C and EN 1994; 7:20–26. 10. Gallop MA, Barrett RW, Dower WJ, Fodor SPA, Gordon EM. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem 1994; 37:1234–1251. 11. Gordon EM, Barrett RW, Dower WJ, Fodor SPA, Gallop MA. Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies and future directions. J Med Chem 1994; 37:1385–1399. 12. Dooley CT, Chung NN, Wolkes BC, Schiller PW, Bidlack JM, Pasternak GW, Houghten RA. An all D-amino acid peptide with central analgesic activity from a combinatorial library. Science 1994; 266:2019–2022. 13. Kerr JM, Banville SC, Zuckermann RN. Encoded combinatorial peptide libraries containing nonnatural amino acids. J Amer Chem Soc 1993; 115:2529–2531. 14. Ohlmeyer MHJ, Swanson RN, Dillard LW, Reader JC, Asouline G, Kobayashi R, Wigler M, Still C. Complex synthetic chemical libraries indexed with molecular tags. Proc Natl Acad Sci USA 1993; 90:10922–10926. 15. Dankwardt SM, Newman SR, Krestenansky JL. Solid phase synthesis of aryl and benzylpiperidines and their application in combinatorial chemistry. Tetrahedron Letters 1995; 36:4923–4926. 16. Baldwin JJ, Burbaum JJ, Henderson I, Ohlmeyer MHJ. Synthesis of a small molecule combinatorial library encoded with molecular tags. J Amer Chem Soc 1995; 117:5588–5589. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_538.html (1 of 2) [4/9/2004 12:50:42 AM]
Document 17. Zuckermann RN, Martin EJ, Spellmeyer DC, Stauber GB, Shoemaker KR, Kerr JM, Figliozzi GM, Goff DA, Siani MA, Simon RJ, Banville SC, Brown EG, Wang L, Richter LS, Moos WH. Discovery of nanomolar ligands for 7-transmembrane G-protein coupled receptors from a diverse N- (substituted)glycine peptoid library. J Med Chem 1994; 37:2678–2685. 18. Burbaum JJ, Ohlmeyer MHJ, Reader JC, Henderson I, Dillard LW, Li G, Randle TL, Sigal NH, Chelsky D, Baldwin JJ. A paradigm for drug discovery employing encoded combinatorial libraries. Proc Natl Acad Sci USA 1995; 92:6027–6031. 19. Lam KS, Salmon SE, Hersh EM, Hruby VJ, Kazmierski WM, Knapp RJ. A new type of synthetic peptide library for identifying ligand-binding activity. Nature 1991; 354:82–84. 20. Loew GH, Villar HO, Alkorta I. Strategies for indirect computer-aided drug design. Pharmaceutical Res 1993; 10:475–486. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_538.html (2 of 2) [4/9/2004 12:50:42 AM]
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netLibrary - eBook Summary Universi
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document Page 56 It is also attract
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 61 now clear that the
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Document Page 67 Biochemical data s
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 45. Majumadar C, Abbotts J
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Document 89. Hughes SH, Arnold E, H
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Figure 1 Retroviral lifecy
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Document Page 88 transfer (Figure 3
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Document Page 92 The role of the N-
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Document Figure 6 Molscript stereo
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Document proposed mechanisms. For e
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 65. Gallay P, Swingler S,
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Document 4 Bradykinin Receptor Anta
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Document Page 125 binding site on t
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Document Page 127 The des-Arg 9 for
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Document Page 129 tolerated by the
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Document receptor, it has not yet b
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Document Page 133 This initial stag
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Document Page 135 might be jointly
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document 39. Mavunkel BJ, Lu Z, Kyl
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Page 182 (SAR) model. The
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Document IX. S2' Interactions Page
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Document Page 207 sure and the acti
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Document Cyclotheonamide A (CtA), a
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Document C. Specificity Figure 4 Th
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Document Figure 5 The S 3 specifici
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Document Figure 13 The identified p
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Document B. Interleukin-1 Receptor
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Document Page 427 These aromatic di
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Document 39. Saurat JH, Schfferli J
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Document 102. Machin PJ, Osbond JM,
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Figure 4 Stereo view of IF
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Document Page 451 with the cytoplas
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Document Page 462 strains of influe
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Document Figure 3 (a) A MOLSCRIPT [
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Document B. Protein Structure Page
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document Page 476 nM, respectively.
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Document 21. Both GW, Sleigh MJ, Co
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Page 679 and 680: Document Figure 2 Stereo view of th
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Page 685 and 686: Document Lists of Bonding Fragment
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Page 689 and 690: Document Page 555 N-acylpyrrolidine
Page 691 and 692: Document 10. Bobbyer DNA, Goodford
Page 693 and 694: Document structure. 2. Ligand probe
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Page 697 and 698: Document 22 Peptidomimetic and Nonp
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Document Figure 32 PTP and PTB 3D s
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document 78. Rodriguez M, Crosby R,
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Document MA, Welch KM, Hallak H, Ta
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document site, 52, 55, 61 triad, 24
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document overview, 103-104, 108-109
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Document [Inhibitors] 2-((3,4-dihyd
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Document antagonistic activity, 416
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Document Kininogen, 119 high molecu
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Document Matrix-metalloproteinase (
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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