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Document Page 455 21. McInnes B, Chambers PJ, Cheetham BF, Beilharz MW, Tymms MJ. Structure-function studies of interferons-α: Amino acid substitutions at the conserved residue tyrosine 123 in human interferon-α 1. J Interferon Res 1989; 9:305–314. 22. Waine GJ, Tymms MJ, Brandt ER, Cheetham BF, Linnane AW. Structure-function study of the region encompassing residues 26–40 of human interferon-α 4: Identification of residues important for antiviral and antiproliferative activities. J Interferon Res 1992; 13:42–48. 23. Ott TL, Van Heeke G, Johnson HM, Bazer FW. Cloning and expression in Saccharomyces cerevisiae of a synthetic gene for the type-1 trophoblast interferon ovine trophoblast protein-1: Purification and antiviral activity. J Interferon Res 1990; 11:357–364. 24. Subramaniam PS, Khan SA, Pontzer CH, Johnson HM. Differential recognition of the type In IFN receptor by IFN-τ and IFN-α is responsible for their differential cytotoxicities. 1995; (submitted). 25. Sander C, Schneider R. Database of homology-derived structure and the structural meaning of sequence alignment. Proteins 1991; 9:56–68. 26. Rost B, Sander J. Prediction of protein structure at better than 70% accuracy. J Mol Biol 1993; 232:544–599. 27. Johnson HM, Langford MP, Lakchaura B, Chan TS, Stanton GJ. Neutralization of native human gamma interferon by antibodies to a synthetic peptide encodded by the 5' end of human gamma interferon cDNA. J Immunol 1982; 129:2357–2359. 28. Langford MP, Gray PW, Stanton GJ, Lakchaura B, Chan T-S, Johnson HM. Antibodies to a synthetic peptide corresponding to the N-terminal end of mouse gamma interferon (IFN-α). Biochem Biophys Res Comm 1983; 117:866–871. 29. Russell JK, Hayes MP, Carter MJ, Torres BA, Dunn BM, Russell SW, Johnson HM. Epitope and functional specificity of monoclonal antibodies to mouse interferon gamma: the synthetic peptide approach. J Immunol 1986; 136:3324–3328. 30. Magazine HI, Carter JM, Russell JK, Torres BA, Dunn BM, Johnson HM. Use of synthetic peptides to identify an N-terminal epitope on mouse gamma interferon that may be involved in function. Proc Natl Acad Sci USA 1988; 185:1237–1241. 31. Jarpe MA, Johnson HM. Topology of receptor binding domains of mouse IFN-α. J Immunol 1990; 145:3304–3309. 32. Griggs ND, Jarpe MA, Pace JL, Russell SW, Johnson HM. The N-terminus and C- terminus of interferon gamma are binding domains for cloned soluble interferon gamma receptor. J Immunol 1992; 149:517–520. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_455.html (1 of 2) [4/9/2004 12:12:22 AM]
Document 33. Szente BE, Johnson HM. Binding of IFN-α and its C-terminal peptide to a cyto-plasmic domain of its receptor that is essential for function. Biochem Biophys Res Comm 1994; 201:215–221. 34. Zavodny PJ, Petro ME, Chiang TR, Narula SK, Leibowitz PJ. Alterations of the amino terminus of murine interferon gamma: expression and biological activity. J Interferon Res 1988; 8:483–494. 35. Arakawa T, Hsu YR, Parker CG, Lai PH. Role of polycationic C-terminal portion in the structure and activity of recombinant human interferon gamma. J Biol Chem 1986; 261:8534–8539. 36. Leinikki PO, Calderon J, Luquette MH, Schreiber RD. Reduced receptor binding by a human interferon gamma fragment lacking 11 carboxyl-terminal amino acids. J Immunol 1987; 139:3360–3366. 37. Wetzel R, Perry LJ, Veilleux C, Chang G. Mutational analysis of the C-terminus of human interferon gamma. Prot Eng 1990; 3:611–623. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_455.html (2 of 2) [4/9/2004 12:12:22 AM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document We determined the structur
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Document 6 Structural Implications
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Page 535 and 536: Document receptor antagonist into a
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Page 541 and 542: Document 17 Structure and Functiona
Page 543 and 544: Document Table 1 Approval Indicatio
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Page 547 and 548: Document II. Type IFNs A great deal
Page 549 and 550: Document Page 441 sequence of the m
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Page 553 and 554: Document Figure 4 Stereo view of IF
Page 555 and 556: Document Figure 5 Velcro-key model
Page 557 and 558: Document Figure 6 Proposed receptor
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Page 583 and 584: Document Page 471 molecules in the
Page 585 and 586: Document hydroxy, and 6 Neu5Ac2en -
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Page 589 and 590: Document Page 476 nM, respectively.
Page 591 and 592: Document Page 478 lished—was asso
Page 593 and 594: Document VI. Conclusion Page 480 It
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Document Figure 4 A ribbon diagram
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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