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Document CHARMM, 542-544 computational combinatorial ligand design (CCLD), 550-552 DELPHI, 383 DOCK, 379-383 MCSS, 542-544 Conformational change, 59, 60, 61, 70 degrees of freedom, 252 protein, 235-237 Congestive heart failure, 295, 296, 298, 301, 314 Cortiso, 193 Cortisone, 193 Cross linking, 137-138 Crystallography cocktail soak approach, 377-379 Crystal structure, 45, 54, 56, 59, 61, 64 aldose reductase, 231-239 other aldo-keto reductases, 240-241 glyceraldehyde-3-phosphate dehydrogenase, 374-375 phosphoglycerate kinase, 376-377, 388 triosephosphate isomerase, 371-373 Cutaneous T-cell lymphoma, 167 Cyclic template, 252 http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_637.html (3 of 4) [4/9/2004 1:52:52 AM]
Document Cyclotheonamide A (CtA), 254 http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_637.html (4 of 4) [4/9/2004 1:52:52 AM]
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netLibrary - eBook Summary Universi
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Structure-based Drug Design 14 Stru
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Document Figure 2 Schematic represe
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Document TF—transframe, PR—prot
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Document compounds that utilize sim
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Document Page 15 Thiazoles are less
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Document Figure 5 Stereo view AG134
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Document Figure 7 Cartoon represent
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Document 35. Kaldor SW, Hammond M,
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Document 47. Tummino PJ, Ferguson D
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Document 60. Condra JH, Schleif WA,
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Document 74. Reddy RM, Varney MD, K
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Document 2 Structural Studies of HI
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Document Figure 1 (a) Chemical stru
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Document dine (3TC), and 2',3'-dide
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Document monophosphate analogs whic
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Document Analysis of various HIV-1
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Document Page 54 Table 2) [12,54].
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Document Page 56 It is also attract
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 61 now clear that the
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Document Page 63 most of the amino
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Document Page 65 cal properties of
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Document Page 67 Biochemical data s
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Document Page 69 determining the me
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 30. Coffin JM. HIV populat
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Document 45. Majumadar C, Abbotts J
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Document reverse transcriptase inhi
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Figure 1 Retroviral lifecy
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Document Figure 2 In vivo reactions
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Document Page 88 transfer (Figure 3
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Document Page 92 The role of the N-
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Document Figure 6 Molscript stereo
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Document Page 96 region in the HIV-
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Document day junction resolving enz
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Document -62° for HIV-1 integrase,
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Document Page 101 crystallized unde
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Document Figure 8 Molscript stereo
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Document proposed mechanisms. For e
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 65. Gallay P, Swingler S,
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 123 were poorly satis
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Document Page 125 binding site on t
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Document Page 127 The des-Arg 9 for
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Document Page 129 tolerated by the
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Document receptor, it has not yet b
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Document Page 133 This initial stag
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Document Page 135 might be jointly
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document 16. Martorana PA, Kettenba
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Document 39. Mavunkel BJ, Lu Z, Kyl
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Figure 5 (a) A cut away vi
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Document Page 182 (SAR) model. The
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Document IX. S2' Interactions Page
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Document Figure 6 (a) The pocket of
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Document 7 Structure—Function Rel
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Document Figure 1 Reactions catalyz
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Document Figure 2 Structure of lico
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Document Figure 3 (Continued) Page
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Document Page 207 sure and the acti
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Document 29. Baker ME. Genealogy of
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Document Page 214 viruses. Specific
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Document Page 218 The catalytic loo
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Document Page 220 conserved substra
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Document Figure 3 (a) Ternary compl
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Document Figure 5 (a) Staurosporine
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Document protein kinase core is ess
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Document 10. Knighton DR, Zheng J-H
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Document 24. Madhusudan Xuong N-H,
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Document 9 Structural Studies of Al
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Document diverse ARIs have been sho
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Document Figure 3 C α trace of the
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Document Figure 4 Surface represent
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Document 10 Structure-Based Design
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Document Cyclotheonamide A (CtA), a
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Document Page 256 The discovery pro
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Document balance its pro- and antic
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Document Lys in the P1 position is
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Document 12 Polypeptide Modulators
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Document A. Chemical Modification P
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Document plasma. This may arise fro
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Document C. Specificity Figure 4 Th
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Document Figure 5 The S 3 specifici
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Document IV. Rational Drug Design F
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Document 17. Szelke M. Chemistry of
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Document Table 1 Trypanosomal Targe
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Document 5-Methoxytryptamine 19.0 9
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Document 65. João HC, Williams RJP
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Document 84. Verlinde CLMJ, Hol WGJ
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Document 16 Progress in the Design
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Document Table 1 Known Three-Dimens
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document Figure 11 Functional resid
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Document Figure 13 The identified p
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Document B. Interleukin-1 Receptor
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Document Page 425 Antinflammatory D
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Document Page 427 These aromatic di
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Document 5. Dinarello CA. On the Bi
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Document 39. Saurat JH, Schfferli J
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Document 74. Bender PE, Lee JC., ed
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Document 102. Machin PJ, Osbond JM,
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Page 443 that allowed for
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Document Figure 4 Stereo view of IF
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Document Figure 5 Velcro-key model
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Document Page 451 with the cytoplas
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Document 33. Szente BE, Johnson HM.
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Document 47. Igarashi K, Garotta G,
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Document Page 462 strains of influe
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Document Page 464 could not again b
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Document Figure 3 (a) A MOLSCRIPT [
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Document B. Protein Structure Page
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Document Figure 5 (a) Stereo image
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document Figure 8 Stereo image of t
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Document Page 476 nM, respectively.
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Document Page 478 lished—was asso
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 40. Drzenick R, Frank H, R
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 486 95. Ryan DM, Tice
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document accommodate a variety of d
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Document Figure 10 Possible hydroge
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Document Page 514 sis. Large number
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Document conformational transition
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Document Figure 3 Generation of com
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Document Figure 8 Minimized structu
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Document Page 555 N-acylpyrrolidine
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Document 30. O'Shea EK, Rutkowski R
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Document Figure 22 Protease 3D stru
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Document Page 601 inhibitors 100 [1
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Document Page 603 hydroxymethyl sub
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Document Figure 28 Protease 3D stru
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Page 755 and 756: Document (Ser/Thr) peptide 2.9 Å 2
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Page 761 and 762: Document Page 617 Val (131) showed
Page 763 and 764: Document Figure 32 PTP and PTB 3D s
Page 765 and 766: Document Acknowledgments Page 620 I
Page 767 and 768: Document 18. Sawyer TK. In: Peptide
Page 769 and 770: Document Page 622 Fukuroda T, Fukam
Page 771 and 772: Document Page 623 53. Bird J, Harpe
Page 773 and 774: Document 78. Rodriguez M, Crosby R,
Page 775 and 776: Document MA, Welch KM, Hallak H, Ta
Page 777 and 778: Document Page 626 SJ, Ogden RC, Red
Page 779 and 780: Document 97; (e) Fujii I, Nakamura
Page 781 and 782: Document Med Biol 1991; 306:9-21; (
Page 783 and 784: Document Page 629 ML, Clare M, Decr
Page 785 and 786: Document Page 630 177. (a) Bode W,
Page 787 and 788: Document Page 631 197. Musil D, Zuc
Page 789 and 790: Document son AH, Drummond AH, Huxle
Page 791 and 792: Document 236. (a) Marshall MS. TIBS
Page 795 and 796: Document 274. (a) Kavanaugh WM, Wil
Page 797 and 798: Document replacements, 563-565 1-am
Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803: Document factors, 247 Combination t
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
Page 819 and 820: Document antagonistic activity, 416
Page 821 and 822: Document [Interleukin-1] homology w
Page 823 and 824: Document Kininogen, 119 high molecu
Page 825 and 826: Document Matrix-metalloproteinase (
Page 827 and 828: Document RT inhibitor, 41, 56 Nonpe
Page 829 and 830: Document Phosphoglycerate kinase (P
Page 831: Document [Protease targets] serinyl
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