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Document 18. Greenfeder SA, Nunes P, Kwee L, Labow M, Chizzonite RA, Ju G, Molecular cloning and characterization of a second subunit of the Interleukin-1 receptor complex. J Biol Chem 1995;270:13757–13765. 19. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Schmidt JA, Tocci M.A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature 1992; 356:768. 20. Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, Huebner K, Black RA. Molecular cloning of the IL-1β processing enzyme. Science 1992; 256:97. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_429.html (2 of 2) [4/9/2004 12:10:07 AM]
Document 21. Seckinger P, Lowenthal JW, Williamson K, Dayeri M, MacDonald HR. A urine inhibitor of interleukin-1 activity that blocks ligand binding. J Immunol 1987; 139:1546. 22. Hannum CH, Wilcox CJ, Arend WP, Joslin FG, Dripps DJ, Heimdal PL, Armes LG, Sommer A, Eisenberg SP, Thompson RC. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 1990; 343:336. 23. Mazzei GJ, Seckinger PL, Dayer JM, Shaw AR. Purification and characterization of a 26-kDa competitive inhibitor of interleukin 1. Eur J Immunol, 1990; 20:683. 24. Haskill S, Manin M, VanLe L, Morris J, Peace A, Bigler CF, Jaffe GJ, Sporn SA, Fong S, Arend WP, Ralph P. cDNA cloning of a novel form of the interleukin-1 receptor antagonist associated with epithelium. Proc Natl Acad Sci USA 1991; 88:3681. Page 430 25. Arend WP. Interleukin-1 receptor antagonist. Adv Immunol 1993; 54:167. 26. Muzio M, Polentarutti N, Sironi M, Pli G, DeGioia L, Introna M, Mantovani A, Colotta F. Characterization of intracellular interleukin-1 receptor antagonist II. Cytokine 1995; 7:632. 27. Kroggel R, Martin M, Pingoud V, Dayer J-M, Resch K. Two Chain structure of the interleukin-1 receptor. FEBS Lett 1988; 229:59. 28. Sims JE, Painter SL, Gow IR. Genomic organization of the type I and type II IL-1 receptors. Cytokine 1995, 7:483–490. 29. Sims JE, GMA, Slack JL, Alderson MR, Bird TA, Gin JG, Colotta F, Re F, Mantovani A, Shanebeck K, Grabstein KH Dower SK. Interleukin-1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci USA 1993; 90:6155–6159. 30. Colotta F, DSK, Sims JE, Mantovani A. The type II “decoy” receptor: A novel regulatory pathway for interleukin-1. Immunol Today 1994; 15:562. 31. Symons JA, Young PA, Duff GW. The soluble interleukin I receptor: Ligand binding properties and mechanisms of release. Lymphokine Cytokine Res 1993; 12:381. 32. Arend WP, Malyak M, Smith MF, Whisenand TD, Slack JL, Sims JE, Giri JG, Dower SK. Binding of IL-1α, IL-1β, and IL-1 receptor antagonist <strong>by</strong> soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J Immunol 1994; 153:4766. 33. Symons JA, Young PA, Duff GW. Differential release and ligand binding of type II IL-1 receptors. Cytokine 1994; 6:555. 34. Hopp TP. Evidence from sequence information that the interleukin-I receptor is a transmembrane GTPase. Protein Sci 1995; 4:1851. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_430.html (1 of 2) [4/9/2004 12:10:13 AM]
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Structure-based Drug Design 14 Stru
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Document Analysis of various HIV-1
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Document 163. Lacey SF, Larder BA.
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Document Page 108 mulate during tre
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Document We determined the structur
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Document Page 166 As predicated, th
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Document 6 Structural Implications
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Document III. Results and Discussio
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Page 525 and 526: Document Page 425 Antinflammatory D
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Page 535 and 536: Document receptor antagonist into a
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Page 541 and 542: Document 17 Structure and Functiona
Page 543 and 544: Document Table 1 Approval Indicatio
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Page 547 and 548: Document II. Type IFNs A great deal
Page 549 and 550: Document Page 441 sequence of the m
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Page 553 and 554: Document Figure 4 Stereo view of IF
Page 555 and 556: Document Figure 5 Velcro-key model
Page 557 and 558: Document Figure 6 Proposed receptor
Page 559 and 560: Document Page 451 with the cytoplas
Page 561 and 562: Document for directed subcellular t
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Page 565 and 566: Document 33. Szente BE, Johnson HM.
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Document 21. Both GW, Sleigh MJ, Co
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Document Figure 5 Some compounds wh
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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