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Document The AdoMet binding motif is similar to the Rossmann fold, which is well known from the nucleotide binding proteins [22]. It has been shown that the known crystal structures of methyltransferases are strikingly similar in the AdoMet-binding regions [23], which indicates that all AdoMet-utilizing enzymes may share a common divergent evolution. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_347.html (2 of 2) [4/5/2004 5:27:50 PM]
Document Figure 5 Schematic stereo view of the three-dimensional structure of COMT. The ligands bound to COMT are the methyl-donating coenzyme AdoMet and the magnesium ion. Figures 5–7 and 13 were produced using the program MOLSCRIPT [50]. Figure 6 Stereo view of the AdoMet binding to COMT. The most important amino acid residues are shown as well as the magnesium ion and the inhibitor 3, 5-dinitrocate-chol (DNC). http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_348.html (1 of 2) [4/5/2004 5:28:03 PM] Page 348
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Structure-based Drug Design 14 Stru
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 125 binding site on t
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Document receptor, it has not yet b
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Document Figure 6 Rat and human B2
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Document Figure 9 Composition of te
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Page 182 (SAR) model. The
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Document IX. S2' Interactions Page
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Document Figure 6 (a) The pocket of
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Document Important for the validity
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Document III. Results and Discussio
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Document Cyclotheonamide A (CtA), a
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Document Page 256 The discovery pro
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Document balance its pro- and antic
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Page 415 and 416: Document 17. Szelke M. Chemistry of
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Page 421 and 422: Document Page 343 14 Structural Asp
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Document 16 Progress in the Design
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Document Table 1 Known Three-Dimens
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document Page 405 strands constitut
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document Page 476 nM, respectively.
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Document Page 495 of the RNA and pr
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Document Figure 5 Some compounds wh
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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