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Document Correlation with inotropic and arrhythmic effects. Eur J Pharmacol 1986; 120:161–170. Page 317 30. Schweitz H, Bidard J-N, Frelin C, Pauron D, Vijverberg HPM, Mahasneh DM, Lazdunski M, Vilbois F, Tsugita A. Purification, sequence and pharmacological properties of sea anemone toxins from Radianthus paumotensis. A new class of sea anemone toxins acting on the sodium channel. Biochemistry 1985; 24:3554–3561. 31. Frelin C, Vigne P, Schweitz H, Lazdunski M. The interaction of sea anemone and scorpion neurotoxins with tetrodotoxin-resistant Na + channels in rat myoblasts. A comparison with Na + channels in other excitable and non-excitable cells. Mol Pharmacol 1984;26:70–74. 32. Platou ES, Refsum H, Hotvedt R. Class III antiarrhythmic action linked with positive inotropy: antiarrhythmic, electrophysiological, and hemodynamic effects of the sea anemone polypeptide ATX II in the dog heart in situ. J Cardiovasc Pharmacol 1986; 8:459–465. 33. Vaughan Williams EM. Classification of antidysrhythmic drugs. Pharmac Therap B 1975; 1:115–138. 34. Sasayama S. What do the newer inotropic drugs have to offer? Cardiovasc Drugs Ther 1992; 6:15–18. 35. Catterall WA. Structure and function of voltage-sensitive ion channels. Science 1988; 242:50–61. 36. Wann KT. Neuronal sodium and potassium channels: structure and function. Br J Anaesthes 1993; 71:2–14. 37. Catterall WA. Structure and function of voltage-gated ion channels. Ann Rev Biochem 1995; 64:493–531. 38. Warashina A, Jiang Z-Y, Ogura T. Potential-dependent action of Anemonia sulcata toxins III and IV on sodium channels in crayfish giant axons. Eur J Physiol 1988; 411:88–93. 39. Warashina A, Ogura T, Fujita S. Binding properties of sea anemone toxins to sodium channels in the crayfish giant axon. Comp Biochem Physiol 1988; 90C:351–358. 40. Driscoll PC, Gronenborn AM, Beress L, Clore GM. Determination of the three-dimensional solution structure of the antihypertensive and antiviral protein BDS-1 from the sea anemone Anemonia sulcata: a study using nuclear magnetic resonance and hybrid distance geometry—dynamical simulated annealing. Biochemistry 1989; 28:2188–2198. 41. Llewellyn LE, Norton RS. Binding of the sea anemone polypeptide BDS II to the voltage-gated sodium channel. Biochem Intl 1991; 24:937–946. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_317.html (1 of 2) [4/5/2004 5:24:13 PM]
Document 42. Catterall WA, Beress L. Sea anemone toxin and scorpion toxin share a common receptor site associated with the action potential sodium ionophore. J Biol Chem 1978; 253:7393–7396. 43. Scholtysik G. Cardiac Na + channel activation as a positive inotropic principle. J Cardiovasc Pharmacol 1989; 14 (Suppl 3):S24–S29. 44. Scholtysik G, Quast U, Schaad A. Evidence for different receptor sites for the novel cardiotonic S- DPI 201-106, ATX II, and veratridine at the cardiac sodium channel. Eur J Pharmacol 1986; 125:111–118. 45. Thomsen WJ, Catterall WA. Localization of the receptor site for α-scorpion toxins by antibody mapping: implications for sodium channel topology. Proc Natl Acad Sci USA 1989; 86:10161–10165. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_317.html (2 of 2) [4/5/2004 5:24:13 PM]
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Document We determined the structur
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document Cyclotheonamide A (CtA), a
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Page 415 and 416: Document 17. Szelke M. Chemistry of
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Page 421 and 422: Document Page 343 14 Structural Asp
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Document All effects of the IL-1 fa
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Document Page 425 Antinflammatory D
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Document Page 427 These aromatic di
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Document 5. Dinarello CA. On the Bi
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Document 39. Saurat JH, Schfferli J
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Page 443 that allowed for
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Document Figure 4 Stereo view of IF
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Document Figure 5 Velcro-key model
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Document Figure 6 Proposed receptor
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Document Page 451 with the cytoplas
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Document for directed subcellular t
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Document Page 462 strains of influe
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Document B. Protein Structure Page
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document Page 476 nM, respectively.
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 40. Drzenick R, Frank H, R
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 486 95. Ryan DM, Tice
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Figure 7 HRV14 VP1 hydroph
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Document Acknowledgments Page 620 I
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 631 197. Musil D, Zuc
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Document site, 52, 55, 61 triad, 24
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document [Inhibitors] 2-((3,4-dihyd
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Document antagonistic activity, 416
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Document Kininogen, 119 high molecu
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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