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Document Page 227 12. Zheng J-H, Knighton DR, Ten Eyck LF, Karlsson R, Xuong N-H, Taylor SS, Sowadski JM. Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 1993; 32:2154–2161. 13. Sowadski JM, Ellis C, Madhusudan. Detergent binding to unmyristylated protein kinase A—structural implications for the role of myristate. Journal of Bioenergetics and Biomembranes 1996; 28:7–12. 14. Knighton DR, Bell S, Xuong N-H, Ten Eyck LF, Taylor SS, Sowadski JM. 2.0Å refined crystal structure of catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. Acta Cryst 1993; D49:357–361. 15. Karlsson RF, Zheng J-H, Xuong N-H, Taylor SS, Sowadski JM. Crystal structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation. Acta Cryst 1993; D49:381–388. 16. Zheng J-H, Knighton DR, Xuong N-H, Taylor SS, Sowadski JM, Ten Eyck LF. Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Proteins Science 1993; 2:1559–1573. 17. Taylor SS, Radzio-Andzelm E. Three protein kinase structures define a common motif. Structure 1994; 2:345–355. 18. Knighton DR, Pearson RB, Sowadski JM, Means AR, Ten Eyck LF, Taylor SS, Kemp BE. Structural basis of the intrasteric regulation of myosin light chain kinase. Science 1992; 258:130–135. 19. Senften M, Schenker G, Sowadski JM, Ballmer-Hofer K. Catalytic activity and transformation potential of v-Src require arginine 385 in the substrate binding pocket. Oncogene 1995; 10:199–203. 20. Karlsson RF, Madhusudan Taylor SS, Sowadski JM. Intermolecular contacts in various crystal forms related to the open and closed conformational states of the catalytic subunit of cAMP-dependent protein kinase. Acta Cryst 1994; D50:657–662. 21. Marcote MJ, Knighton DR, Basi G, Sowadski JM, Brambilla P, Draetta G, Taylor SS. A threedimensional model of the cdc2 protein kinase: identification of cyclin and suc1 binding regions. Molecular and Cellular Biology 1993; 13:5122–5133. 22. Songyang, Z et al., Catalytic specificity of protein tyrosine kinase is critical for selective signalling. Nature 1991; 373:536–539. 23. Ho M-F, Bramson HN, Hansen DE, Knowles JR, Kaiser ET. Stereochemical course of the phospho group transfer catalyzed by cAMP-dependent protein kinase. J Am Chem Soc 1988; 110:2680–2681. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_227.html (1 of 2) [4/5/2004 5:07:40 PM]
Document 24. Madhusudan Xuong N-H, Ten Eyck LF, Taylor SS, Sowadski JM. cAMP-dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer. Protein Science 1994; 3:176–187. 25. Furet P, Caravattti G, Priestle J, Sowadski J, Trinks U, Traxler P. Modeling study of protein kinase inhibitors: Binding mode of staurosporine-origin of the selectivity of CGP 52 411. J Comp Aid Mol Design 1995; 9:465–472. 26. Azevedo WF Jr, Mueller-Diechmann H-J, Schulze-Gahmen U, Worland PJ, Sausville E, Kim S-H. Proc Natl Acad Sci 1996; In press. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_227.html (2 of 2) [4/5/2004 5:07:40 PM] 27. Kraulis PJ, MOLSCRIPT—A program to produce both detailed and schematic plots of protein structures. Journal of Applied Crystallography 1991; 24:946–950.
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document Figure 5 Velcro-key model
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 40. Drzenick R, Frank H, R
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Page 495 of the RNA and pr
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Document Figure 5 Some compounds wh
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document Page 622 Fukuroda T, Fukam
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Document Page 626 SJ, Ogden RC, Red
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document 236. (a) Marshall MS. TIBS
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Document 274. (a) Kavanaugh WM, Wil
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document [Inhibitors] 2-((3,4-dihyd
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Document antagonistic activity, 416
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Document Kininogen, 119 high molecu
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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