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Document Page 634 258. (a) Zhang M, Van Etten RL, Stauffacher CV. Biochem 1994; 33:11097–11105; (b) Barford D, Flint AJ, Tonks NK. Science 1995; 263:1397–1404; (c) Jia Z, Barford D, Flint AJ, Tonks NK. Science 1995; 268:1754–1758. 259. Yuvaniyama J, Denu JM, Dixon JE, Saper MA. Science 1996; 272:1328–1331. 260. Goldberg J, Huang H-B. Kwon Y-G, Greengard P, Nairn AC, Kuriyan J. Nature 1995; 376:745–753. 261. Eck MJ, Dhe-Paganon S, Trub T, Nolte RT, Shoelson SE. Cell 1996; 65:695–705. 262. Zhou M-M, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trub T, Shoelson SE, Fesik SW. Nature (Struct Biol) 1996; 3:388–393. 263. Pflugl G, Kallen J, Scuirmer T, Jansonius JN, Zurini MGM, Walkinshaw MD. Nature 1993; 361:91–94. 264. Van Duyne GD, Standaert RG, Karplus PM, Schreiber SL, Clardy J. Science 1991; 252:839–842. 265. Saltiel AR. Scientific American (Sci Med) 1995; 2:58–67. 266. Bridges AJ. Chemtracts (Org Chem) 1995; 8:73–107. 267. Huber HE, Koblan KS, Heimbrook DC. Curr Med Chem 1994; 1:13–34. 268. (a) Cohen GB, Ren R, Baltimore D. Cell 1995; 80:237–248; (b) Liu X, Pawson T. Recent Prog Hormone Res 49:149–160; (c) Fry MJ, Panayotou G, Booker GW, Waterfield MD. Protein Sci 1993; 2:1785–1797. 269. Cantley LC, Songyang Z. J Cell Sci 1994; 18 (Suppl):121–126. 270. Shahripour A, Para KS, Plummer MS, Lunney EA, Stankovic CJ, Holland DR, Rubin JR, Humblet C, Fergus JH, Marks JS, Saltiel AR, Sawyer TK. Bioorg Med Chem 1997; in press.. 271. Shahripour A, Plummer MS, Lunney EA, Para KS, Stankovic CJ, Rubin JR, Humblet C, Fergus JH, Marks JS, Herrera R, Hubbell SE, Saltiel AR, Sawyer TK. Bioorg Med Chem Lett 1996; 6:1209–1214. 272. Zhang Y-Z, Maclean D, McNamara DJ, Sawyer TK, Dixon JE, Biochemistry 1994; 33:2285–2290. 273. Burke TR Jr, Kole HK, Roller PP. Biochem Biophys Res Comm 1994; 204:129–134. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_634.html (1 of 2) [4/9/2004 1:50:06 AM]
Document 274. (a) Kavanaugh WM, Williams LT. Science 1994; 266:1862–1865; (b) Kavanaugh WM, Turck CW, Williams LT. Science 1995; 268:1177–1179. 275. Eck MJ. <strong>Structure</strong> 1995; 3:421–424. 276. (a) Thompson LA, Ellman JA. Chem Rev 1996; 96:555–600; (b) Patel DV, Gordon EM. <strong>Drug</strong> Disc Today 1996; 1:134–144; (c) Chen JK, Schreiber SL. Angew Chem Int Ed Engl 1995; 34:953–969; (d) Andrews P, Cody WL, Leonard DM, Sawyer TK. In: Pennington MW, Dunn BM, Eds. Peptide Synthesis and Purification Protocols. Vol. II. Humana Press, 1994:305–328; (e) Zuckermann RN. Curr Opinion Struct Biol 1993; 3:580–584; (f) Pavia MR, Sawyer TK, Moos WH. Bioorg Med Chem Lett 1993; 3:387–396; (g) Jung G, Beck-Sickinger AG. Angew Chem Int Ed Engl 1992; 31:367–486. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_634.html (2 of 2) [4/9/2004 1:50:06 AM]
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Structure-based Drug Design 14 Stru
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Figure 1 Retroviral lifecy
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 127 The des-Arg 9 for
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Document receptor, it has not yet b
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Document Page 133 This initial stag
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Figure 5 (a) A cut away vi
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Document Page 182 (SAR) model. The
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Document IX. S2' Interactions Page
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
Page 819 and 820: Document antagonistic activity, 416
Page 821 and 822: Document [Interleukin-1] homology w
Page 823 and 824: Document Kininogen, 119 high molecu
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Page 827 and 828: Document RT inhibitor, 41, 56 Nonpe
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