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Document 161. (a) Kalish VJ, Tatlock JH, Davies JF II, Kaldor SW, Dressman BA, Reich S, Pino M, Nyugen D, Appelt K, Musick L, Wu B-W. Bioorg Med Chem Lett 1995; 5:727-; (b) Kalish V, Kaldor S, Shetty B, Tatlock J, Davies J, Hammond M, Dressman B, Fritz J, Appelt K, Reich S, Musick L, Wu BW, Su K. Eur J Med Chem 1995; 30:S201-. 162. (a) Kim EE, Baker CT, Dwyer MD, Murko MA, Rao BG, Tung RD, Navia MA. J Am Chem Soc 1995; 117:1181-; (b) Partaledis JA, Yamaguchi K, Tisdale M, Blair EE, Falcione C, Maschera B, Myers RE, Pazhanisamy S, Futer O, Culliman AB, Stuver CM, Byrn RA, Livingston DJ. J Virology 1995; 69:5228–5235. 163. (a) Getman DP, DeCrescenzo GA, Heintz RM, Reed KL, Talley JJ, Bryant ML, Clare M, Houseman KA, Mar JJ, Mueller RA, Vazquez ML, Shieh H-S, Stallings WC, Stegeman RA. J Med Chem 1993; 36:288–291; (b) Vazquez ML, Bryant http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_628.html (2 of 2) [4/9/2004 1:47:40 AM]
Document Page 629 ML, Clare M, Decrescenzo GA, Doherty EM, Freskos JN, Getman DP, Houseman KA, Julien JA, Kocan GP, Mueller RA, Shieh HS, Stallings WC, Stegeman RA, Talley JJ. J Med Chem 1995; 38:581. 164. (a) Desjarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz DeMontellano PR, DeCamp DL, Babe LM, Craik CS. Proc Natl Acad Sci USA 1990; 87:6644–6648; (b) Rutenbar E, Fauman EB, Keenan RJ, Fong S, Furth PS, Ortiz de Montellano PR, Meng E, Kuntz ID, DeCamp DL, Salto R, Rose JR, Craik CS. Strand RM. J Biol Chem 1993; 268:15343–15346. 165. Vara Prasad JVN, Para KS, Lunney EA, Ortwine DF, Dunbar JB, Jr Ferguson D, Tummino PJ, Hupe D, Tait BD, Domagala JM, Humblet C, Bhat TN, Liu TN, Buerin DMA, Baldwin ET, Erickson JW, Sawyer TK. J Am Chem Soc 1994; 116:6989–6990. 166. Thaisrivongs S, Watenpaugh KD, Howe WJ, Tomich PK, Dolak LA, Chong KT, Tomich CSC, Tomasselli AG, Turner SR, Strohbach JW, Mulichack AM, Janakiraman MN, Moon JB, Lynn JC, Horng MM, Hinshaw RR, Curry KA, Rothcrock DJ. J Med Chem 1995; 38:3624–3637. 167. Skulnick HI, Johnson PD, Howe WJ, Tomich PK, Chong KT, Watenpaugh KD, Janakiraman MN, Dolak LA, McGrath JP, Lynn JC, Horng MM, Hinshaw RR, Zipp GL, Ruwart MJ, Schwende FJ, Zhong WZ, Padbury GE, Dalga RJ, Shiou LH, Possert PL, Rush BD, Wilkinson KF, Howard GM, Toth LN, Williams MG, Kakuk TJ, Cole SL, Zaya TM, Lovasz KD, Morris JK, Romines KR, Thaisrivongs S, Aristoff PA. J Med Chem 1995; 38:4968–4971. 168. Tummino PJ, Vara Prasad JVN, Ferguson D, Nouhan C, Graham N, Domagala JM, Ellsworth E, Gadja C, Hagen SE, Lunney EA, Para KS, Tait BD, Pavlosky A, Erickson JW, Gracheck S, McQuade TJ, Hupe DJ. Bioorg Med Chem. 1996; 4: 1401–1410. 169. (a) Navia MA, Fitzgerald PM, McKeever BM, Leu CT, Heimbach JC, Herber WK, Sigal IS, Darke PL, Springer JP. Nature 1989; 337:615–620; (b) Wlodawer A, Miller M, Jaskolski M, Sathyranarayana BK, Baldwin E, Weber IT, Selk LM, Clawson L, Schneider J, Kent SB. Science 1989; 245:616–621. 170. Miller M, Schneider J, Sathyanarayana BK, Toth MV, Marshall GR, Clawson L, Selk L, Kent SBH, Wlodawer A, Science 1989; 246:1149–1152. 171. Jaskolski M, Tomasselli AG, Sawyer TK, Staples DJ, Heinrikson RL, Schneider J, Kent SBH, Wlodawer A. Biochem 1991; 30:1600–1609. 172. Swain AL, Miller MM, Green J, Rich DH, Schneider J, Kent SBH, Wlodawer A. Proc Natl Acad Sci USA 1990; 87:8805–8809. 173. Fitzgerald PMD, McKeever BM, Van Middlesworth JF, Springer JP, Heimbach JC, Leu C-T, Herber WK, Dixon AF, Darke PL. J Biol Chem 1990; 265:14209–14219. 174. Weber PC, Ohlendorf DH, Wendoloski JJ, Salemme FR. Science 1989; 243:85–88. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_629.html (1 of 2) [4/9/2004 1:47:58 AM]
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netLibrary - eBook Summary Universi
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Structure-based Drug Design 14 Stru
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Document 74. Reddy RM, Varney MD, K
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Document 2 Structural Studies of HI
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Document monophosphate analogs whic
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Document Analysis of various HIV-1
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Document Page 54 Table 2) [12,54].
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Document Page 56 It is also attract
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 61 now clear that the
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Document Page 65 cal properties of
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Document Page 67 Biochemical data s
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Document Page 69 determining the me
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 30. Coffin JM. HIV populat
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Document reverse transcriptase inhi
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 163. Lacey SF, Larder BA.
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Document Figure 1 Retroviral lifecy
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Document Figure 2 In vivo reactions
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Document Page 88 transfer (Figure 3
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Document Page 92 The role of the N-
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Document Figure 6 Molscript stereo
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Document Page 96 region in the HIV-
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Document -62° for HIV-1 integrase,
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Document Page 101 crystallized unde
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Document proposed mechanisms. For e
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 65. Gallay P, Swingler S,
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 125 binding site on t
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Document Page 127 The des-Arg 9 for
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Document receptor, it has not yet b
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document IX. S2' Interactions Page
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Document Cyclotheonamide A (CtA), a
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Document A. Chemical Modification P
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Document IV. Rational Drug Design F
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Document 17. Szelke M. Chemistry of
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document B. Protein Structure Page
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Page 799 and 800: Document inhibitor binding, 323, 33
Page 801 and 802: Document site, 52, 55, 61 triad, 24
Page 803 and 804: Document factors, 247 Combination t
Page 805 and 806: Document Cyclotheonamide A (CtA), 2
Page 807 and 808: Document D ddI, 152 tumour necrosis
Page 809 and 810: Document antistasin peptides, 281 c
Page 811 and 812: Document fragment-based programs, 5
Page 813 and 814: Document [Human immunodeficiency vi
Page 815 and 816: Document overview, 103-104, 108-109
Page 817 and 818: Document [Inhibitors] 2-((3,4-dihyd
Page 819 and 820: Document antagonistic activity, 416
Page 821 and 822: Document [Interleukin-1] homology w
Page 823 and 824: Document Kininogen, 119 high molecu
Page 825 and 826: Document Matrix-metalloproteinase (
Page 827 and 828: Document RT inhibitor, 41, 56 Nonpe
Page 829 and 830: Document Phosphoglycerate kinase (P
Page 831: Document [Protease targets] serinyl
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