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Document Page 339 3. Pearl LH, Blundell TL. The active sites of aspartic proteinases. FEBS Lett 1984; 174:96–101. 4. Sibanda BL, Blundell TL, Hobart PM, Fogliano M, Bindra JS, Dominy BW, Chirgwin JM. Computer graphics modeling of human renin. FEBS Lett 1984; 174:102–111. 5. Skeggs LT, Dover FE, Levine M, Lentz KE, Kahn JR. In: Johnson JA, Anderson RR, ed. The Renin- Angiotensin System. New York: Plenum. 6. Bone R, Silen JL, Agard DA. Structural plasticity broadens the specificity of an engineered protease. Nature 1989; 339:191–195. 7. Haber E, Burton J. Inhibitors of renin and their utility in physiologic studies. Fedn Proc 1979; 38:2768–2773. 8. Cooper JB, Bailey D. A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica. Protein Science 1994, 3:2129–2143. 9. Foundling SI, Cooper, J, Watson FE, Cleasby A, Pearl LH, Sibanda BL, Hemmings A, Wood SP, Blundell TL, Valler MJ, Norey CG, Kay J, Boger J, Dunn BM, Leckie BJ, Jones DM, Atrash B, Hallett A, Szelke M. High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes. Nature (London) 1987; 327:349–352. 10. Luly JR, Bolis G, Bamaung N, Soderquist J, Dellaria JF, Stein H, Cohen J, Thomas JP, Greer J, Plattner JJ. New inhibitors of human renin that contain novel replacements. Examination of the P 1 site. J Med Chem 1988; 31:532–539. 11. Hofmann T, Fink AL. Cryoenzymology of penicillopepsin. Biochemistry 1984; 23:5249–5256. 12. Szelke M, Leckie B, Hallett A, Jones DM, Sueiras-Diaz J, Atrash B, Lever AF. Potent new inhibitors of human renin. Nature 1982; 299:555–557. 13. Boger J. Renin inhibitors. Design of angiotensin transition state analogues containing statine. In: Kostka V. ed. Aspartic Proteinases and Their Inhibitors. Berlin: Walter de Gruyter, 1985:401–420. 14. Kokubu T, Hiwada K, Murakami E, Imamura Y, Matsueda R, Yabe Y, Koike H, Iijima Y. Highly potent and specific inhibitors of human renin. Hypertension 1985; 7 (suppl.1):8–11. 15. Kokubu T, Hiwada K, Nagae A, Murakami E, Morisawa Y, Yabe Y, Koike H, Iijima Y. Statine containing dipeptide and tripeptide inhibitors of human renin. Hypertension (Suppl.II) 1986; 8:1–5. 16. Gelb MH, Svaren JP, Abeles RH. Fluoroketone inhibitors of hydrolytic enzymes. Biochemistry 1985; 24:1813–1817. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_339.html (1 of 2) [4/5/2004 5:27:13 PM]
Document 17. Szelke M. Chemistry of renin inhibitors. In: Kostka V, ed. Aspartic Proteinases and Their Inhibitors. Berlin: Walter de Gruyter, 1985:421–441. 18. Sham HL, Stein HH, Rempel CA, Cohen J and Plattner JJ. Highly potent and specific inhibitors of human renin. FEBS Lett 1987; 220:299–301. 19. Cooper JB, Foundling SI, Blundell TL, Boger J, Jupp R, Kay J. X-ray studies of aspartic proteinasestatine inhibitor complexes. Biochemistry 1989; 28:8596–8603. 20. Arrowsmith RJ, Carter K, Dann JG, Davies DE, Harris CJ, Morton JA, Lister P, Robinson JA, Williams DJ. Novel renin inhibitors: synthesis of aminostatine and comparison with statine-containing analogues. J Chem Soc Chem Commun 1986; 10:755–757. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_339.html (2 of 2) [4/5/2004 5:27:13 PM] 21. Jones M, Sueiras-Diaz J, Szelke M, Leckie B, Beattie S. Renin inhibitors containing the novel amino-acid 3aminodeoxystatine. In: Deber CM, Hruby VJ, Kopple
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Document 60. Condra JH, Schleif WA,
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Document 74. Reddy RM, Varney MD, K
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Document 2 Structural Studies of HI
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Document dine (3TC), and 2',3'-dide
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Document monophosphate analogs whic
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Document Analysis of various HIV-1
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Document Page 54 Table 2) [12,54].
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Document Page 56 It is also attract
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 61 now clear that the
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Document Page 65 cal properties of
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Document Page 67 Biochemical data s
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Document Page 69 determining the me
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 30. Coffin JM. HIV populat
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Document 45. Majumadar C, Abbotts J
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Document reverse transcriptase inhi
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Document 89. Hughes SH, Arnold E, H
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Figure 1 Retroviral lifecy
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Document Figure 2 In vivo reactions
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Document Page 88 transfer (Figure 3
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Document Page 92 The role of the N-
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Document Figure 6 Molscript stereo
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Document day junction resolving enz
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Document Figure 8 Molscript stereo
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Document proposed mechanisms. For e
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document Page 121 Nearly all cells
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Document Page 125 binding site on t
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Document Page 127 The des-Arg 9 for
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Document receptor, it has not yet b
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document 16. Martorana PA, Kettenba
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document position eight from formin
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document Page 182 (SAR) model. The
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Document IX. S2' Interactions Page
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Page 395 and 396: Document 13 Rational Design of Reni
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Page 421 and 422: Document Page 343 14 Structural Asp
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Document 65. João HC, Williams RJP
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Document 16 Progress in the Design
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Document Table 1 Known Three-Dimens
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Document Page 398 with growth hormo
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Document All effects of the IL-1 fa
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Document Figure 4 (a) Stereo diagra
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Document Figure 6 (a) Stereo diagra
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Document Figure 7 (a) Superposition
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Document Figure 11 Functional resid
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Document Figure 13 The identified p
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Document B. Interleukin-1 Receptor
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Document Page 423 American Home Pro
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Document Page 425 Antinflammatory D
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Document Page 427 These aromatic di
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Document 5. Dinarello CA. On the Bi
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Document 39. Saurat JH, Schfferli J
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Document 74. Bender PE, Lee JC., ed
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Document 17 Structure and Functiona
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Document Table 1 Approval Indicatio
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Document Page 438 proteins. One pot
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Document II. Type IFNs A great deal
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Document Page 441 sequence of the m
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Document Page 443 that allowed for
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Document Figure 4 Stereo view of IF
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Document Figure 5 Velcro-key model
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Document Figure 6 Proposed receptor
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Document Page 451 with the cytoplas
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Document for directed subcellular t
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Document Page 462 strains of influe
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Document Figure 3 (a) A MOLSCRIPT [
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Document B. Protein Structure Page
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Document Page 471 molecules in the
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Document hydroxy, and 6 Neu5Ac2en -
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Document Figure 8 Stereo image of t
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Document Page 476 nM, respectively.
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Document Page 478 lished—was asso
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Document VI. Conclusion Page 480 It
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Document 21. Both GW, Sleigh MJ, Co
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document 80. Suzuki Y, Sato K, Kiso
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Document Page 486 95. Ryan DM, Tice
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Subsequent studies have sh
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Figure 7 HRV14 VP1 hydroph
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Document C. Structure-Activity Rela
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Document Figure 10 Possible hydroge
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Document Page 514 sis. Large number
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Document conformational transition
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Document Page 527 function. Iterati
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Document Figure 3 Generation of com
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Document 21 Structure-Based Combina
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Document 10. Bobbyer DNA, Goodford
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Document 30. O'Shea EK, Rutkowski R
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Document 22 Peptidomimetic and Nonp
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Document Acknowledgments Page 620 I
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Document 18. Sawyer TK. In: Peptide
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Document MA, Welch KM, Hallak H, Ta
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document 274. (a) Kavanaugh WM, Wil
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Document site, 52, 55, 61 triad, 24
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Document factors, 247 Combination t
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Kininogen, 119 high molecu
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Document RT inhibitor, 41, 56 Nonpe
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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