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Document 35. Bendtzen K, Svenson M, Jonsson V, Hippe E. Autoantibodies to cytokines-Friends or foes? Immunol Today 1990; 11:167. 36. Svenson M, Hensen MB, Bendtzen K. Distribution and characterization of autoantibodies to interleukin-1α in normal human sera. Scand J Immunol 1990; 32:695. 37. Svenson M, Hensen MB, Kayser L, Rasmussen AK, Reimert CM, Bendtzen K. Effects of human anti-IL-1α autoantibodies on receptor binding and biological activities of IL-1. Cytokine 1992; 4:125. 38. Satoh H, Chizzonite R, Ostrowski C, Ni-Wu G, Kim H, Fayer B, Mae N, Nadeau R, Liberato DJ. Characterization of antiIL-1α autoantibodies in the sera from healthy humans. Immunopharmacology 1994; 27:107. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_430.html (2 of 2) [4/9/2004 12:10:13 AM]
Document 39. Saurat JH, Schfferli J, Steiger G, Dayer J-M, Didierjean L. Anti-interleukin-1α auto antibodies in humans. J Allergy Clin Immunol 1991; 88:244. 40. Preistle JP, Schar H-P, Grutter MG. Crystallographic Refinement of Interleukin 1β at 2.0 Å Resolution. Proc Natl Acad Sci USA 1989; 86:9667–9671. Page 431 41. Finzel BC, Clancy LL, Holland DR, Muchmore SW, Watenpaugh K, Einspahr HM. Crystal structure of recombinant human interleukin-1β at 2.0 Å resolution. J Mol Biol, 1989; 209:779–791. 42. Veerapandian B, Gilliland GL, Raag R, Svensson AL, Masui Y, Hirai Y, Poulos TL. Functional implications of interleukin-1β bases on the three-dimensional structure. Proteins: Struct, Funct Genet 1992; 12:10–23. 43. Clore GM, Wingfield PT, Gronenborn AM. High resolution three dimensional structure of interleukin-1β in solution by three and 4 dimensional nuclear magnetic spectroscopy. Biochemistry 1991; 30:2315–2319. 44. Ohlendorf DHT, A, Weber PC, Wondolski JJ, Salemme FR, Lischwe M, Newton RC. A comparison of the high resolution structures of human and marine interleukin-1β to be published. 45. Graves BJ, Hatada MH, Hendnckson WA, Miller JK, Madison VS, Satow Y. Structure of interleukin- 1α at 2.7 A resolution. Biochemistry 1990; 29:2679– 2684. 46. Stockman BJS, TA, Strakalaitis NA, Brunner DP, Yem AW, Deibel MR Jr. Solution structure of human interleukin-1 receptor antagonist protein. FEBS Letters 1994; 349:79–83. 47. Vigers GPA, Caffes P, Evans RJ, Thompson RC, Eisenberg SP, Brandhuber BJ. X-ray structure of interleukin-1 receptor antagonist at 2.0 Å resolution. J of Biol Chem 1994; 269:12874–12879. 48. Schreuder HAR, J-M, Tardif C, Soffientini A, Sarubbi E, Akeson A, Bowlin TL, Yanofsky S, Barrett RW. Crystal structure of the interleukin-1 receptor antagonist. To be published. 49. Spraggon G, Singh O, Stuart DI, Jones EY. The crystal structure of intact interleukin-1 receptor antagonist. To be published. 50. Wilson KPB, JF, Thomson JA, Kim EE, Griffith JP, NAvia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, Livingston DJ. Structure and mechanism of interleukin-1β converting enzyme. Nature 1994; 370:270–275. 51. McLachlan AD. Three-fold structural pattern in the soybean trypsin inhibitor (Kunitz). J Mol Biol 1979; 133:557–563. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_431.html (1 of 2) [4/9/2004 12:10:17 AM]
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Structure-based Drug Design 14 Stru
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Document 74. Reddy RM, Varney MD, K
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Document 2 Structural Studies of HI
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Document dine (3TC), and 2',3'-dide
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Document Analysis of various HIV-1
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Document Table 3 HIV-1 RT Amino Aci
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Document Page 67 Biochemical data s
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Document reverse transcriptase inhi
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Page 88 transfer (Figure 3
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document receptor, it has not yet b
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Document Page 135 might be jointly
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document B. Pharmacology Figure 1 T
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document position eight from formin
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Page 178 studies show that
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Document IX. S2' Interactions Page
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 202 269, and valine-2
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Document Figure 6 Structure of α h
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Document Page 205 enzyme and of phe
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Page 497 and 498: Document All effects of the IL-1 fa
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Page 519 and 520: Document Figure 13 The identified p
Page 521 and 522: Document B. Interleukin-1 Receptor
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Page 525 and 526: Document Page 425 Antinflammatory D
Page 527 and 528: Document Page 427 These aromatic di
Page 529 and 530: Document 5. Dinarello CA. On the Bi
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Page 535 and 536: Document receptor antagonist into a
Page 537 and 538: Document 74. Bender PE, Lee JC., ed
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Page 541 and 542: Document 17 Structure and Functiona
Page 543 and 544: Document Table 1 Approval Indicatio
Page 545 and 546: Document Page 438 proteins. One pot
Page 547 and 548: Document II. Type IFNs A great deal
Page 549 and 550: Document Page 441 sequence of the m
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Page 553 and 554: Document Figure 4 Stereo view of IF
Page 555 and 556: Document Figure 5 Velcro-key model
Page 557 and 558: Document Figure 6 Proposed receptor
Page 559 and 560: Document Page 451 with the cytoplas
Page 561 and 562: Document for directed subcellular t
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Page 565 and 566: Document 33. Szente BE, Johnson HM.
Page 567 and 568: Document 47. Igarashi K, Garotta G,
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Page 579 and 580: Document B. Protein Structure Page
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Document Page 476 nM, respectively.
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Document 21. Both GW, Sleigh MJ, Co
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Document 45. Varghese JN, Laver WG,
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Document 64. Ward CW, Elleman TC, A
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Document Page 488 against most of t
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Document A. The Canyon Page 491 The
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Document Page 495 of the RNA and pr
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Document Figure 4 A ribbon diagram
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Document Figure 5 Some compounds wh
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Document Acknowledgments Page 620 I
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Document 78. Rodriguez M, Crosby R,
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Document 97; (e) Fujii I, Nakamura
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Document Med Biol 1991; 306:9-21; (
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Document Page 629 ML, Clare M, Decr
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Document Page 630 177. (a) Bode W,
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Document Page 631 197. Musil D, Zuc
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Document son AH, Drummond AH, Huxle
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Document 236. (a) Marshall MS. TIBS
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Document Cyclotheonamide A (CtA), 2
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Document D ddI, 152 tumour necrosis
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Document antistasin peptides, 281 c
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Document fragment-based programs, 5
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Document [Human immunodeficiency vi
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Document Phosphoglycerate kinase (P
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Document [Protease targets] serinyl
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