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Document 52. Murzin AG, Lesk AM, Chothia C. b- Trefoil Fold: patterns of structure and sequence in the kunitz inhibitors interleukins-1β and 1α and fibroblast growth factors. J Mol Biol 1992; 223:531–543. 53. Ohelndorf DH. Accuracy of refined proteins structures II. Comparison of four independantly refined models of interleukin-1β. Acta Cryst 1994; D50:808–812. 54. Yuan J, Shaam S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β converting enzyme. Cell 1993; 75:641–652. 55. Labriola-Tompkins E, Chandran C, Kaffka K L, Biondi D, Graves BJ, Hatada M, Madison VS, Karas J, Klian PL, Ju G. Identification of the discontinuous binding site in human interleukin-1β for the type I interleukin-1 receptor. Proc Natl Acad Sci USA 1991; 88:11182–11186. 56. Ju G, Labriola-Tompkins E, Campen CA, Benjamin WR, Karas J, Plocinski J, Biondi D, Kaffka KL, Klian PL, Eisenberg SP, Evans RJ. Conversion of the IL-1 http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_431.html (2 of 2) [4/9/2004 12:10:17 AM]
Document receptor antagonist into an agonist by a single amino acid substitution. Proc Natl Acad Sci USA 1991; 88:2658–2662. Page 432 57. Kawashima H, Yamagishi J, Yamayoshi M, Ohue M, Fukwi T, Kotani H, Yamada M. Structureactivity relationships in human interleukin-1α: identification of key residues for expression of biological activities. Protein Eng 1992; 5–2:171–176. 58. Labriola-Tompkins E, Chandran C, Varnell TA, Madison VS, Ju G. Structure-function analysis of human IL-1α: Identification of residues required for binding to the human type I IL-1 receptor. Protein Eng 1993; 6–5:535–539. 59. Guinet F, Guitton J, Gault N, Folliard F, Touchet N, Cherel J, Crespo A, Destourbe A, Bertrand P, Denefle P, Mayaux J, Bousseau A, Duchesne M, Terlain B, Cartwright T. Interleukin-1β specific partial agonists defined by site-directed mutagenesis studies. Eur J Biochem 1993; 211:583–590. 60. Grutter MG, van Oostrum J, Pnestle JP, Edelmann E, Joss U, Feige U, Vosbeck K, Schmitz A. Protein Eng, 1994; 7:663–671. 61. Greenfeder SA, Varnell T, Powers G, Lombard-Gillooly K, Shuster D, McIntyre KW, Ryan DE, Leven W, Madison V, Ju G. Insertion of a structural domain of interleukin-1β confers agonist activity to the IL-1 receptor antagonist. J Biol Chem 1995; 270:22460–22466. 62. Wolfson AJ, Kanaoka M, Lau F, Ringe D, Young P, Lee J, and Blumenthal J. Biochemistry 1993; 32:5327–5331. 63. Simoncsits A, Bnstulf J, Tjornhammar ML, Cserzo M, Pongor S, Rybakina E, Gatti S, Bartfai T. Cytokine 1994; 6:206–214. 64. Antoni G, Presentini R, Penn F, Tagliabue A, Ghiara P, Censini S, Volpini G, Villa L, Boraschu D. J Immunol 1986; 137:3201. 65. Boraschi D, Nencioni L, Villa L, Censini S, Bossu P, Ghiara P, Presentini R, Perin F, Frasca D, Dona G, Forni G, Musso T, Giovarelli M, Ghezzi R, Bertini R, Besedovsky H, Del Rey A, Sipe J, Anotoni G, Silvestn S, Tagliabue A. J Exp Med 1988; 168:675–686. 66. Frasca D, Boraschi D, Baschien S, Bossu P, Tagliabue A, Adorini L, Dona GJ Immunol 1988; 141:2651–2655. 67. Beckers W, Villa L, Gonfloni S, Castagnoli L, Newton SMC, Cesareni, Ghiara P. J Immunol 1993; 151:1757–1764. 68. Joss UR, Schmidli I, Vosbeck K. Mapping the receptor binding domain of interleukin-1β by means of binding studies using overlapping fragments: Why did it fail? J Recept Res 1991; 11:275–282. http://legacy.netlibrary.com/nlreader/nlReader.dll?bookid=12640&filename=Page_432.html (1 of 2) [4/9/2004 12:10:20 AM]
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Structure-based Drug Design 14 Stru
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Document 74. Reddy RM, Varney MD, K
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Document 2 Structural Studies of HI
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Document Analysis of various HIV-1
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Document Page 54 Table 2) [12,54].
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Document Page 56 It is also attract
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Document Table 3 HIV-1 RT Amino Aci
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Document ever, once an NNRTI is bou
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Document Page 67 Biochemical data s
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Document Page 69 determining the me
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Document Chris Tantillo. The work i
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Document Page 72 16. Goldman ME, Nu
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Document 45. Majumadar C, Abbotts J
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Document reverse transcriptase inhi
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Document 89. Hughes SH, Arnold E, H
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Document 106. Cirino NM, Cameron CE
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Document 122. Marshall WS, Beaton G
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Document dine) and didanosine (dide
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Document 149. Craig JC, Duncan IB,
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Document 163. Lacey SF, Larder BA.
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Document Page 92 The role of the N-
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Document Page 106 on the same ring
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Document Page 108 mulate during tre
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Document when metals are bound. Fin
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Document cubation of phosphotyrosin
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Document 4 Bradykinin Receptor Anta
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Document receptor, it has not yet b
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Document Page 137 observed for the
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Document Figure 6 Rat and human B2
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Document Page 141 receptor with int
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Document Figure 9 Composition of te
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Document We determined the structur
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Document Figure 3 Previously known
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Document large solvent channels and
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Document IV. Drug Design Progressio
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Document Table 1 Inhibition Data fo
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Document Page 166 As predicated, th
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Document References 1. Parks RE Jr.
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Document 17. Ealick SE, Rule SA, Ca
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Document 6 Structural Implications
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Document Figure 1 A ribbon model of
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Document Page 176 0.43 Å) as the c
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Document Important for the validity
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Document Figure 4 Amino acids impor
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Document III. Results and Discussio
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Document Page 205 enzyme and of phe
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